Value of detection of mitogen-activated protein kinase 4 combined with vimentin in early diagnosis of endometrial cancer

  Objective  To study the diagnostic value of combined detection of mitogen-activated protein kinase 4(MAP2K4) and vimentin in diagnosis of endometrial cancer.

  Methods  A total of 103 patients with endometrial cancer were selected as study subjects. MAP2K4 and vimentin were detected respectively, and diagnostic value of combined detection was explored.

  Results  The endometrial cancer-positive rate detected by MAP2K4 was significantly lower than that of vimentin37.86% (39/103) vs. 65.05%(67/103), the proportion score and staining intensity score of positive cells were also significantly lower than those of vimentin(P < 0.05). The positive expression of MAP2K4 was significantly correlated with FIGO staging and lymph node metastasis, while the positive expression of vimentin was significantly correlated with FIGO staging, histological types, invasion depth and lymph node metastasis (P < 0.05). The sensitivity and specificity of combined detection of MAP2K4 and vimentin were significantly higher than that of single detection(P < 0.05).

  Conclusion  The combined detection of MAP2K4 and vimentin has obvious effect in the diagnosis of endometrial cancer, which can provide reference for prognosis.