Significance of coagulation function and glycosylated hemoglobin in judging the progression of diabetes

  Objective  To analyze the clinical significance of coagulation function and glycosylated hemoglobin in judging the progression of diabetes.

  Methods  A total of 98 patients with diabetes mellitus treated in our hospital were selected, among whom 50 newly diagnosed diabetic patients were as observation A group, and the other 48 patients accompanying by microvascular complications were as observation B group. Another 50 healthy people in the hospital for physical examination at the same time were selected as control group. The glycosylated hemoglobin(HbAlc), fasting blood glucose (FPG), and levels of coagulation function thrombin time(TT), activated partial thromboplastin time(APTT), prothrombin time(PT), fasting blood glucose(Fbg) in the two groups was compared.

  Results  The levels of FPG and HbAlc in group A and group B were significantly higher than those in control group (P < 0.05), and observation B group was significantly higher than observation A group (P < 0.05). The APTT, TT, PT and Fbg in group B were significantly lower than those in observation A group and control group (P < 0.05). However, there was no significant difference in the above indexes between observation A group and control group (P>0.05).

  Conclusion  Clinical monitoring of blood coagulation function and glycosylated hemoglobin level in diabetic patients is of great significance in providing accurate basis for the diagnosis, especially for diabetic patients with microvascular complications.