LIU Kaimei, HAN Chongxu. Value of urine culture combined with urine β2-microglobulin in diagnosis of location of simple urinary tract infection[J]. Journal of Clinical Medicine in Practice, 2019, 23(20): 74-77. DOI: 10.7619/jcmp.201920020
Citation: LIU Kaimei, HAN Chongxu. Value of urine culture combined with urine β2-microglobulin in diagnosis of location of simple urinary tract infection[J]. Journal of Clinical Medicine in Practice, 2019, 23(20): 74-77. DOI: 10.7619/jcmp.201920020

Value of urine culture combined with urine β2-microglobulin in diagnosis of location of simple urinary tract infection

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  • Received Date: August 02, 2019
  • Revised Date: September 27, 2019
  • Available Online: February 28, 2021
  • Published Date: October 27, 2019
  •   Objective  To explore the value of urine culture and urine β2-microglobulin (β2-MG) in the diagnosis of location of simple urinary tract infection.
      Methods  A total of 143 patients with simple urinary tract infections diagnosed as simple urinary tract infection in the Department of Urology in Subei People′s Hospital, among whom 52 patients with upper urinary tract infections were as upper urinary tract group, 91 patients with lower urinary tract infections were as lower urinary tract group, and 22 patients with physical examination at the same time were as control group. Midstream urine culture and urine β2-MG were detected before treatment.
      Results  The positive rate of urine culture in upper urinary tract group was 78.8%, the proportion of increase of β2-MG level was 84.6%, and the main pathogens were Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa, and the positive rate of urine culture in lower urinary tract group was 90.1%, and the proportion of increase of β2-MG level was 5.5%. The main pathogenic bacteria were Escherichia coli, Enterococcus faecalis and Candida albicans. The positive rate of urine culture in the control group was 4.5% and the proportion of increase of β2-MG level was 4.5%. There was no significant difference in urine culture results between upper and lower urinary tract groups (P>0.05), but there was significant difference in β2-MG (P < 0.01).
      Conclusion  Urinary culture combined with β2-MG has good diagnostic value in the localizationof simple upper and lower urinary tract infections, as well as the flora distribution and empirical medication.
  • [1]
    Kangari G, Esteghamati M, Ghasemi K, et al. Predictive accuracy of urinary β2-microglobulin for kidney injury in children with acute pyelonephritis[J]. Iran J Kidney Dis, 2015, 9(1): 19-24. http://www.ncbi.nlm.nih.gov/pubmed/25599732
    [2]
    Jung N, Byun H J, Park J H, et al. Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection[J]. Korean J Pediatr, 2018, 61(1): 24-29. doi: 10.3345/kjp.2018.61.1.24
    [3]
    Garcia R, Spitzer E D. Promoting appropriate urine culture management to improve health care outcomes and the accuracy of catheter-associated urinary tract infections[J]. Am J Infect Control, 2017, 45(10): 1143-1153. doi: 10.1016/j.ajic.2017.03.006
    [4]
    Hilt E E, McKinley K, Pearce M M, et al. Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder[J]. J Clin Microbiol, 2014, 52(3): 871-876. doi: 10.1128/JCM.02876-13
    [5]
    帅丽华, 卢敏, 洪霞, 等. 多指标联合检测对尿路感染的临床应用价值探讨[J]. 实验与检验医学, 2013, 31(5): 456-459. doi: 10.3969/j.issn.1674-1129.2013.05.020
    [6]
    Kalinderi K, Delkos D, Kalinderis M, et al. Urinary tract infection during pregnancy: current concepts on a common multifaceted problem[J]. J Obstet Gynaecol, 2018, 38(4): 448-453. doi: 10.1080/01443615.2017.1370579
    [7]
    中国女医师协会肾脏病与血液净化专委会. 中国女性尿路感染诊疗专家共识[J]. 中华医学杂志, 2017, 97(36): 2827-2832. doi: 10.3760/cma.j.issn.0376-2491.2017.36.010
    [8]
    Robinson D, Giarenis I, Cardozo L. The management of urinary tract infections in octogenarian women[J]. Maturitas, 2015, 81(3): 343-347. doi: 10.1016/j.maturitas.2015.04.014
    [9]
    陆金金, 刘海浪, 朱伟, 等. 2012年~2015年男性住院病人尿路感染病原菌的分布及其耐药性分析[J]. 临床外科杂志, 2019(2): 113-116. doi: 10.3969/j.issn.1005-6483.2019.02.008
    [10]
    Heidler S, Bretterbauer K, Schwarz S, et al. Diversity of bacterial urine and prostate gland tissue cultures in patients undergoing transurethral prostate gland resection[J]. Urol Int, 2016, 97(3): 336-339. doi: 10.1159/000448336
    [11]
    Provencher L M, Fairbanks A M, Abramoff M D, et al. Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome[J]. J Ophthalmic Inflamm Infect, 2018, 8(1): 2431. doi: 10.1186/s12348-018-0166-3/fulltext.html
    [12]
    Shin J R, Kim S M, Yoo J S, et al. Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy[J]. Korean J Intern Med, 2014, 29(3): 334-340. doi: 10.3904/kjim.2014.29.3.334
    [13]
    Nishijima T, Kurosawa T, Tanaka N, et al. Urinary β2 -microglobulin can predict tenofovir disoproxil fumarate-related renal dysfunction in HIV-1-infected patients who initiate tenofovir disoproxil fumarate-containing antiretroviral therapy[J]. AIDS, 2016, 30(10): 1563-1571. doi: 10.1097/QAD.0000000000001070
    [14]
    Bartoli F, Penza R, Aceto G, et al. Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction[J]. J Pediatr Surg, 2011, 46(3): 530-536. doi: 10.1016/j.jpedsurg.2010.07.057
    [15]
    Coorevits L, Heytens S, Boelens J, et al. The resident microflora of voided midstream urine of healthy controls: standard versus expanded urine culture protocols[J]. Eur J Clin Microbiol Infect Dis, 2017, 36(4): 635-639. doi: 10.1007/s10096-016-2839-x
    [16]
    Foxman B. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden[J]. Infect Dis Clin North Am, 2014, 28(1): 1-13. doi: 10.1016/j.idc.2013.09.003
    [17]
    Kauffman C A. Diagnosis and management of fungal urinary tract infection[J]. Infect Dis Clin North Am, 2014, 28(1): 61-74. doi: 10.1016/j.idc.2013.09.004
    [18]
    孟红宇. 糖尿病合并尿路感染患者致病菌及敏感药物筛查[J]. 医学检验与临床, 2019(1): 54-55, 66. doi: 10.3969/j.issn.1673-5013.2019.01.016
    [19]
    夏生俊, 施勇, 浦金贤, 等. 经皮肾镜取石术患者术前中段尿培养、肾盂尿培养和肾结石培养结果一致性分析及其与术后感染的关系[J]. 中国医师进修杂志, 2019(3): 225-229.
    [20]
    尿路感染诊断与治疗中国专家共识编写组. 尿路感染诊断与治疗中国专家共识(2015版): 尿路感染抗菌药物选择策略及特殊类型尿路感染的治疗建议[J]. 中华泌尿外科杂志, 2015, 36(4): 245-248. doi: 10.3760/cma.j.issn.1000-6702.2015.04.002
    [21]
    Waller T A, Pantin S A L, Yenior A L, et al. Urinary tract infection antibiotic resistance in the United States[J]. Prim Care, 2018, 45(3): 455-466. doi: 10.1016/j.pop.2018.05.005
    [22]
    刘敬涛, 王连渠, 徐国良. 126例慢性肾盂肾炎患者中段尿细菌培养及耐药性分析[J]. 内蒙古医学杂志, 2019, 51(2): 182-183. https://www.cnki.com.cn/Article/CJFDTOTAL-NMYZ201902023.htm
    [23]
    González Rodríguez J D, Canalejo D, Martín Govantes J J, et al. Proteinuria in urinary infection and acute pyelonephritis in paediatric patients: can it replace scintigraphic studies in diagnostic localisation[J]. Nefrologia, 2009, 29(2): 163-169. http://europepmc.org/abstract/med/19396323

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