Objective To explore the application value of preoperative serum antithrombin Ⅲ(AT-Ⅲ) in predicting postoperative liver failure in patients with hepatocellular carcinoma.
Methods A total of 31 patients who underwent liver cancer surgery in our hospital were divided into hepatic failure group and non-failure group according to the recovery of liver function after hepatectomy. The routine liver function indexes and AT-Ⅲ activity were compared between the two groups, and the risk factors of hepatic failure after hepatectomy were explored.
Results There were significant differences in total bilirubin, AT-Ⅲ activity, albumin, platelet and international standardized ratio between the two groups (P < 0.05). Logistic multivariate analysis showed that total bilirubin and AT-Ⅲ were independent risk factors of liver failure after hepatectomy (P < 0.05). ROC curve analysis showed that the best critical value of AT-Ⅲ for predicting liver failure after operation was 87.2%. The sensitivity and specificity were 0.807 and 0.716, respectively, which showed a significant difference compared with serum total bilirubin (P < 0.05).
Conclusion AT-Ⅲ is an independent risk factor for hepatic failure after hepatocellular carcinoma operation, which has higher sensitivity and specificity in predicting hepatic failure after operation than serum total bilirubin.
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