Effect of compound Shenqi Granules on inflammatory factors and immune function of children with recurrent respiratory tract infection

  Objective  To investigate the effect of compound Shenqi Granules on inflammatory factors and immune function of children with recurrent respiratory tract infection.

  Methods  Totally 60 children with recurrent respiratory tract infection were randomly divided into observation group and control group, with 30 cases in each group. The control group was given routine symptomatic treatment, while the observation group was given compound Shenqi Granules on the basis of the control group. The levels of serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6) and immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), complement C₃ and C₄ were compared before and after treatment.

  Results  Before treatment, there were no significant differences in the levels of IL-2, IL-4 and IL-6 between the two groups (P>0.05). After treatment, the levels of IL-2 and IL-4 increased and IL-6 decreased in both groups, and the levels of IL-2 and IL-4 in the observation group were significantly higher than those in the control group, while the level of IL-6 was significantly lower than that in the control group (P < 0.05). Before treatment, there were no significant differences in the expressions of IgA, IgM, IgG, complement C₃ and C₄ between the two groups (P>0.05). After treatment, the expressions of IgA increased, the expressions of IgM, IgG, complement C₃ and C₄ decreased, and the expression of IgA in the observation group was significantly higher than that in the control group, while the expressions of IgM, IgG, complement C₃ and C₄ in the observation group were significantly lower than those in the control group (P < 0.05).

  Conclusion  Compound Shenqi Granules can regulate the levels of inflammatory factors and enhance the immune function of children with recurrent respiratory tract infection.