Objective To explore effects of vitamin D combined with budesonide and ipratropium bromide on pulmonary function and immune function in children with asthma.
Methods Totally 82 children with asthma were randomly divided into two groups, with 41 cases in each group. The control group was treated with budesonide combined with compound ipratropium bromide, while the study group was treated with vitamin D on the basis of the control group. The curative effect, lung function indexes peak expiratory flow (PEF), maximum expiratory volume in the first second (FEV1), forced vital capacity (FVC), disappearance time of main clinical symptoms (cough, wheeze, lung rale), serum 25-hydroxyvitamin D3 25-(OH)-D3, total immunoglobulin E (IgE), CD4+, CD8+, CD4+/CD8+ levels were compared between the two groups. Correlation between vitamin D and PEF, FEV1, FVC, IgE, CD4+, CD8+, CD4+/CD8+ were analyzed.
Results The total effective rate in the study group was significantly higher than that in the control group (P < 0.05). After treatment, PEF, FEV1 and FVC in the study group were significantly better than those in the control group (P < 0.05). The disappearance time of cough and lung rale in the study group was significantly shorter than that in the control group (P < 0.05). The levels of serum 25-OH-D3, CD4+, CD4+/CD8+ in the study group were significantly higher than those in the control group (P < 0.05), and the levels of IgE and CD8+ in the study group were significantly lower than those in the control group (P < 0.05). Pearson correlation analysis showed that vitamin D level was negatively correlated with IgE level and positively correlated with CD4+/CD8+.
Conclusion On the basis of budesonide combined with compound ipratropium bromide aerosol inhalation therapy, vitamin D can improve the efficiency, improve the relevant indicators of pulmonary function, enhance the immunity of children and alleviate airway inflammation.
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