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DENG Qunhua, WANG Runqing. Effect of methylprednisolone combined with azithromycin on levels of serum inflammatory factors in children with lobar pneumonia[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 75-78. DOI: 10.7619/jcmp.201917021
Citation: DENG Qunhua, WANG Runqing. Effect of methylprednisolone combined with azithromycin on levels of serum inflammatory factors in children with lobar pneumonia[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 75-78. DOI: 10.7619/jcmp.201917021
shu

Effect of methylprednisolone combined with azithromycin on levels of serum inflammatory factors in children with lobar pneumonia

  • 1.

    Zhouzhi County People′s Hospital, Xi′an, Shaanxi, 710499

  • 2.

    Hancheng People′s Hospital, Weinan, Shaanxi, 715401

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  • Received Date: June 11, 2019
  • Accepted Date: August 20, 2019
  • Available Online: February 28, 2021
  • Published Date: September 14, 2019
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the efficiency of glucocorticoids (GCs) combined with azithromycin in treatment of children with lobar pneumonia and its influence on levels of serum inflammatory factors.
      Methods  Totally 118 children with lobar pneumonia were randomly divided into control group and observation group, with 59 cases in each group. The control group was treated with azithromycin, and the observation group was treated with methylprednisolone plus azithromycin. The therapeutic effect, symptoms, signs and changes of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT) and other inflammatory factors were compared between the two groups.
      Results  The fever regression time, cough and rale disappearance time, lung shadow absorption time, hospitalization time, and levels of serum CRP, TNF-α, IL-6 and PCT in the observation group were significantly better than those in the control group (P < 0.05), and the total effective rate was significantly higher than that in the control group (P < 0.05).
      Conclusion  GCs combined with azithromycin is effective in the treatment of children with lobar pneumonia, which can quickly alleviate clinical symptoms and signs, shorten the course of disease, and the safety isgood.
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    • References (20)
  • [1]
    王春侠, 吴建英, 李英. 1例儿童大叶性肺炎合并胸腔积液的护理[J]. 中日友好医院学报, 2016, 30(5): 328-328. doi: 10.3969/j.issn.1001-0025.2016.05.026
    [2]
    孙倩, 刘伟, 杨红秀. 儿童大叶性肺炎159例病原谱及临床分析[J]. 现代中西医结合杂志, 2010, 19(29): 3718-3720. doi: 10.3969/j.issn.1008-8849.2010.29.016
    [3]
    李雅杰, 张全新, 李锋, 等. 河北唐山地区不同年龄段儿童社区获得性大叶性肺炎病原学分析及细菌耐药性研究[J]. 陕西医学杂志, 2018, 47(3): 401-403. doi: 10.3969/j.issn.1000-7377.2018.03.041
    [4]
    邢娜, 宋丽君. 儿童大叶性肺炎570例临床分析[J]. 中国妇幼保健, 2010, 25(2): 195-197. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201002026.htm
    [5]
    吴跃进, 孙节, 张建华, 等. 糖皮质激素辅助治疗儿童肺炎支原体大叶性肺炎的疗效[J]. 中国当代儿科杂志, 2014, 16(4): 401-405. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201404025.htm
    [6]
    倪凯华, 赵建美, 肖钦志, 等. 糖皮质激素对大叶性肺炎患儿血清TNF-α、IL-6、IL-8水平的影响[J]. 现代生物医学进展, 2015, 15(23): 4512-4514. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201523030.htm
    [7]
    张秀军, 王建华, 尉理梁. 川芎嗪注射液联合阿奇霉素序贯治疗大叶性肺炎及迁延性肺炎的临床研究[J]. 中国临床药理学杂志, 2017, 33(8): 675-677. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201708001.htm
    [8]
    邹丽萍, 袁瑞. 儿童大叶性肺炎76例临床分析[J]. 中国当代儿科杂志, 2011, 13(12): 995-996. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201112019.htm
    [9]
    陈园园. 清肺解毒汤治疗90例儿童大叶性肺炎临床疗效及安全性研究[D]. 郑州: 河南中医药大学, 2016.
    [10]
    高建波. 痰热清联合阿奇霉素治疗小儿支原体感染致大叶性肺炎疗效观察[J]. 陕西中医, 2017, 38(4): 452-453. doi: 10.3969/j.issn.1000-7369.2017.04.021
    [11]
    岳保珠, 吴春莲, 刘丽平. 儿童肺炎支原体感染性大叶性肺炎10年发病研究[J]. 医学综述, 2010, 16(13): 2071-2073. doi: 10.3969/j.issn.1006-2084.2010.13.054
    [12]
    肖智辉, 吴本清, 周克英. 深圳市住院儿童社区感染大叶性肺炎53例临床分析[J]. 中国小儿急救医学, 2014, 21(9): 577-578. doi: 10.3760/cma.j.issn.1673-4912.2014.09.009
    [13]
    宋远, 钟旭丽. 儿童使用阿奇霉素胃肠道不良反应分析[J]. 山西医药杂志, 2015, 44(7): 787-788. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY201507027.htm
    [14]
    周鹏翔, 梁舒瑶, 翟所迪. 《儿科阿奇霉素注射使用的快速建议指南》实施方案介绍[J]. 中国药房, 2018, 29(4): 436-440. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA201804002.htm
    [15]
    Ceccato A, Ferrer M, Gabarrus A, et al. Benefits of co-administration of macrolides and glucocorticosteroids in the treatment of severe community acquired pneumonia[J]. European Respiratory Journal, 2016, 48(suppl 60): OA3328-OA3337. http://ofid.oxfordjournals.org/content/3/suppl_1/1236.full
    [16]
    王淑会, 季伟, 严永东, 等. 小儿肺炎支原体支气管肺炎和大叶性肺炎的临床与免疫特征[J]. 江苏医药, 2015, 41(7): 767-769. https://www.cnki.com.cn/Article/CJFDTOTAL-YIYA201507009.htm
    [17]
    古智兵, 王俭, 万光平, 等. 阿奇霉素联合小剂量糖皮质激素对儿童大叶性肺炎炎症相关指标影响分析[J]. 中华医院感染学杂志, 2017, 27(17): 4012-4015. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201717047.htm
    [18]
    杨琳东, 张延峰. 糖皮质激素辅助治疗儿童肺炎支原体大叶性肺炎的疗效分析[J]. 河北医学, 2017, 23(7): 1135-1139. doi: 10.3969/j.issn.1006-6233.2017.07.024
    [19]
    陶旭云, 屈弘宇. 小剂量甲泼尼龙三联疗法治疗儿童难治性大叶性肺炎支原体肺炎的临床疗效及安全性研究[J]. 实用心脑肺血管病杂志, 2015, 23(9): 74-76. doi: 10.3969/j.issn.1008-5971.2015.09.023
    [20]
    田恬, 赵文静, 高颂轶, 等. 甲泼尼龙联合阿奇霉素治疗儿童肺炎支原体大叶性肺炎的疗效[J]. 药物评价研究, 2018, 41(1): 126-129. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ201801024.htm
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