Relationship between platelet count and severity of patients with agkistrodon bite and its effect on prognosis

  Objective  To observe the correlation between platelet count and severity of agkistrodon bite, and its effect on the prognosis of the disease.

  Methods  All patients with agkistrodon bite were divided into normal platelet group and thrombocytopenia group. The clinical indexes such as glutamic-pyruvic transaminase(ALT), serum creatinine(Cr), creatine kinase(CK), oxygenation index and C reactive protein(CRP) and erythrocyte sedimentation(ESR) were compared between the two groups. Meanwhile, the incidence of systemic inflammatory response syndrome(SIRS) and multiple organ dysfunction syndrome(MODS)in both groups were compared. The prognosis of the two groups was observed after treatment.

  Results  There were significant differences in ALT and CK levels in two groups (P < 0.05). The incidence of SIRS, MODS in the thrombocytopenia group were higher than that of normal platelet group (P < 0.05). Patients in thrombocytopenia group had a poor prognosis, the between-group difference was statistically significant(P < 0.05).

  Conclusion  Being prone to occurring SIRS and MODS, agkistrodon bite patients with thrombocytopenia are usually in more serious condition, and have poor prognosis.