Clinical effect of eperisone hydrochloride in the treatment of children with spastic cerebral palsy

  Objective  To explore the clinical effect of eperisone hydrochloride in the treatment of children with spastic cerebral palsy.

  Methods  A total of 84 children with spastic cerebral palsy in our hospital were selected. According to the random number table method, these patients were assigned to group Ⅰ(eperisone hydrochloride treatment group), group Ⅱ(benzhexol hydrochloride treatment group) and group Ⅲ(clonazepam treatment group). The therapeutic effect, relief conditions of muscular tension and incidence of adverse reactions were compared.

  Results  The therapeutic efficacy in group Ⅰwas better than group Ⅱand group Ⅲ(P < 0.05). Before treatment, the muscular tension in three groups showed no statistically significant differences (P>0.05); after treatment, it was greatly improved in three groups, and the muscular tension scores in group Ⅰand group Ⅲwere lower than group Ⅱ(P < 0.05). The incidence of adverse reactions was the highest in group Ⅲ, and lowest in group Ⅰ(P < 0.05).

  Conclusion  Eperisone hydrochloride can remarkably relieve the dystonia and increase the clinical safety.