Objective To explore expression levels of interleukin-17(IL-17) and interleukin-35(IL-35)in serum of patients with missed abortion(MA) and clinical significance.
Methods Thirty MA patients admitted to our hospital from March to September 2017 were selected as case group. Another 30 patients with requirement of early pregnancy termination during the same period of pregnancy were as control group. The peripheral blood was collected before abortion surgery, and the levels of IL-17 and IL-35 were detected by enzyme-linked immunosorbent assay(ELISA).
Results The case group had higher serum IL-17, and lower IL-35 than the control group (P < 0.05). The expression level of IL-17 was negatively correlated with IL-35 level in serum of two groups(r=-0.756, P < 0.05).
Conclusion The occurrence of missed abortion may be related to the high expression of IL-17 and low expression of IL-35.
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