Objective To study the efficacy and hemorheological mechanism of butylphthalide (NBP) combined with Danshen and Ligustrazine Injection in the treatment of cerebral infarction (CIS).
Methods A total of 74 patients with CIS in our hospital were selected and divided into two groups according to the random number table method, with 37 cases in each group. The two groups were given symptom-targeted supportive treatment such as dehydration, anti-platelet aggregation and brain cell nutrition. In addition, control group was treated with Danshen and Ligustrazine, and observation group was given intravenous infusion of NBP on the basis of control group.
Results The efficacy rate in observation group was significantly higher than that in control group (97.30% vs. 83.78%, P < 0.05). At 2 weeks of treatment, the National Institute of Health Stroke Scale (NIHSS) scores in the two groups were significantly decreased (P < 0.05), while the scores of Montreal Cognitive Assessment Scale (MoCA) and Activity of Daily Life (ADL) were significantly increased (P < 0.05), and the observation group had lower NIHSS score while higher scores of MoCA and ADL than those in control group (P < 0.05). The hemorheological indexes such as HSV, LSV, PSV, HCT and ESR were significantly decreased in the two groups (P < 0.05), and the highwhole blood viscosity (HSV), low whole blood viscosity (LSV), plasma viscosity (PSV), hematokrit (HCT) anderythrocyte sedimentation rate (ESR) in the observation group were lower than those in control group(P < 0.05). The incidence of adverse reactions of two groups showed no significnat difference (P>0.05).
Conclusion Danshen and Ligustrazine Injection combined with NBP for cerebral infarction can improve hemodynamic parameters, reduce neurological function and cognitive impairment, improve independent living ability and enhance treatment effects.
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