Effect of levothyroxine combined with Yougui Pill in treatment of pregnant patients complicated with subclinical hypothyroidism

  Objective  To investigate the effect of levothyroxine combined with Yougui Pill in treatment of pregnant patients complicated with subclinical hypothyroidism.

  Methods  Ninety pregnant patients complicated with subclinical hypothyroidism were randomly divided into control group (n=40) and observation group (n=50). The control group was treated with levothyroxine, while the observation group was treated levothyroxine and Yougui Pill. The clinical effect was compared between the two groups.

  Results  There were significant differences in serum thyroid stimulating hormone (TSH), symptom score, homocysteine (Hcy), superoxide dismutase (SOD), 25-hydroxyvitamin-D 25-(OH)-D, folic acid and pregnancy outcome between the two groups after treatment (P < 0.05).

  Conclusion  Levothyroxine combined with Yougui Pill is effective in treatment of pregnant patients complicated with subclinical hypothyroidism, which can improve thyroid function and pregnancy outcome.