Clinical efficacy of dexmedetomidine in children with sevoflurane anesthesia

  Objective  To investigate the clinical efficacy of dexmedetomidine in children with sevoflurane anesthesia.

  Methods  The clinical data of 85 children who underwent tonsillectomy and adenoidectomy were analyzed. The recruited patients were randomly divided into observation group (45 cases, treated by dexmedetomidine) and control group (40 cases, without dexmedetomidine treatment). The baseline data, heart rate (HR) in different time points, mean arterial pressure (MAP), incidence of restlessness (EA), Children Hospital of Eastern Onterin Pain Scale (CHEOPS) score and Pediatric Anesthesia Emergence Delirium Scale (PAED) scores, postoperative incidence of adverse reactions were compared between the two groups.

  Results  There was no significant difference in baseline data between the two groups (P > 0.05). The HR value at T₁, T₂ and T₃ of the observation group was significantly higher, and the MAP level was significantly lower than that of the control group (P < 0.05); the incidence of EA, PAED and CHEOPS scores of the observation group at T₁ and T₂ were significantly lower than those of the control group (P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.01).

  Conclusion  Dexmedetomidine can effectively stabilize the hemodynamics of sevoflurane anesthesia patients, reduce the incidence of restlessness during anesthesia recovery and the incidence of adverse reactions after operation.