QIN Ni, MI Ting, DUAN Ya′nan. Analysis in related factors of 28-day mortality in sepsis patients[J]. Journal of Clinical Medicine in Practice, 2019, 23(14): 76-79. DOI: 10.7619/jcmp.201914020
Citation: QIN Ni, MI Ting, DUAN Ya′nan. Analysis in related factors of 28-day mortality in sepsis patients[J]. Journal of Clinical Medicine in Practice, 2019, 23(14): 76-79. DOI: 10.7619/jcmp.201914020

Analysis in related factors of 28-day mortality in sepsis patients

More Information
  • Received Date: May 19, 2019
  • Accepted Date: June 25, 2019
  • Available Online: February 23, 2021
  • Published Date: July 27, 2019
  •   Objective  To explore the high-risk factors of 28-day mortality in sepsis patients.
      Methods  The clinical materials of 168 patients with sepsis were retrospectively analyzed. Defining the death within 28 days after diagnosis as the end point, the related factors of death was analyzed.
      Results  Age, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, shock, C reactive protein (CRP), lactic acid (Lac) were the independent risk factors of 28-day mortality in sepsis patients (OR>1, P < 0.05), while VitD was an independent protective factor (OR < 1, P < 0.05). The values of area under curve (AUC) of receiver operating characteristic curve (ROC) of the factors mentioned above were significantly larger than the reference line (P < 0.05).
      Conclusion  The 28-day mortality of sepsis patients is independently affected by age, APACHE Ⅱscore, shock, CRP, Lac, and VitD.
  • [1]
    贺小丽, 李德渊, 乔莉娜, 等. 脓毒症流行病学及预后的研究进展[J]. 中华危重病急救医学, 2018, 30(5): 486-489. doi: 10.3760/cma.j.issn.2095-4352.2018.05.019
    [2]
    张卉, 童亚林, 姚咏明. 脓毒症凝血功能紊乱的治疗策略[J]. 临床急诊杂志, 2016, 17(8): 577-580. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZLC201608001.htm
    [3]
    魏锋, 洪志敏, 董海涛, 等. ICU重度脓毒症的流行病学特点及预后影响因素的分析[J]. 中华医院感染学杂志, 2018, 28(10): 37-39, 52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201810007.htm
    [4]
    罗红敏. 全球脓毒症发生率及病死率的估计[J]. 中华危重病急救医学, 2016, 28(8): 722-722.
    [5]
    Rhodes A, Evans L E, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock[J]. Crit Care Med, 2017, 45(3): 486-552. doi: 10.1097/CCM.0000000000002255
    [6]
    Lee H, Lim C W, Hong H P, et al. Efficacy of the APACHE Ⅱ score at ICU discharge in predicting post-ICU mortality and ICU readmission in critically ill surgical patients[J]. Anaesth Intensive Care, 2015, 43(2): 175-186. doi: 10.1177/0310057X1504300206
    [7]
    刘超, 毛智, 周飞虎. 老年脓毒症的研究进展[J]. 解放军医学杂志, 2017, 42(6): 563-568. https://www.cnki.com.cn/Article/CJFDTOTAL-JFJY201706017.htm
    [8]
    曹兴, 廖雪莲, 贺小丽, 等. 老年脓毒症患者远期病死率及生活质量的预测因素分析[J]. 四川大学学报: 医学版, 2018, 49(1): 140-144. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYK201801030.htm
    [9]
    Chen X, Zhu W, Tan J, et al. Early outcome of early-goal directed therapy for patients with sepsis or septic shock: a systematic review and meta-analysis of randomized controlled trials[J]. Oncotarget, 2017, 8(16): 27510-27519. doi: 10.18632/oncotarget.15550
    [10]
    Grek A, Booth S, Festic E, et al. Sepsis and Shock Response Team: Impact of a Multidisciplinary Approach to Implementing Surviving Sepsis Campaign Guidelines and Surviving the Process[J]. Am J Med Qual, 2017, 32(5): 500-507. doi: 10.1177/1062860616676887
    [11]
    王家胜, 陈勇, 康小兰, 等. 脉搏指示连续心排血量监测在脓毒性休克患者早期液体复苏及治疗中的应用[J]. 检验医学与临床, 2016, 13(5): 619-622. doi: 10.3969/j.issn.1672-9455.2016.05.017
    [12]
    严慧芳, 殷站茹, 杜晓宁, 等. CRP及降钙素原联合检测评估脓毒症患儿预后的临床研究[J]. 实用临床医药杂志, 2016, 20(01): 173-175. doi: 10.7619/jcmp.201601065
    [13]
    章晋辉, 赵群, 邹圣强. 降钙素原、C-反应蛋白、白细胞计数在脓毒症患者预后评估中的作用[J]. 中国医药导报, 2016, 13(13): 32-35. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201613008.htm
    [14]
    王春梅, 唐伦先, 徐慧晖, 等. 老年脓毒症患者血浆降钙素原和乳酸浓度动态变化特征及其预后意义[J]. 同济大学学报: 医学版, 2018, 39(1): 89-93. https://www.cnki.com.cn/Article/CJFDTOTAL-TJIY201801018.htm
    [15]
    Khater W S, Salah-Eldeen N N, Khater M S, et al. Role of suPAR and Lactic Acid in Diagnosing Sepsis and Predicting Mortality in Elderly Patients[J]. Eur J Microbiol Immunol(Bp), 2016, 6(3): 178-185. doi: 10.1556/1886.2016.00011
    [16]
    尹冰如, 钱素云, 成怡冰, 等. 脓毒症/严重脓毒症患儿维生素D水平与预后[J]. 中华急诊医学杂志, 2016, 25(6): 709-713. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201901032.htm
    [17]
    Ratzinger F, Haslacher H, Stadlberger M, et al. 25(OH)D and 1, 25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study[J]. Sci Rep, 2017, 7(1): 40646-40646. http://www.ncbi.nlm.nih.gov/pubmed/28318176
    [18]
    邵换璋, 王存真, 朱文亮, 等. 辛伐他汀对脓毒症和严重脓毒症患者外周血单核细胞Toll样受体4的影响[J]. 中华危重病急救医学, 2016, 22(2): 159-163. https://www.cnki.com.cn/Article/CJFDTOTAL-DYBF201610011.htm
    [19]
    李锐, 邢静, 王为, 等. 脓毒症及严重脓毒症患者外周血转化生长因子-β1的表达变化及其在炎症反应中的作用[J]. 中国急救医学, 2016, 36(3): 215-218.
    [20]
    吴忠辉. 急诊脓毒症死亡风险评分对脓毒症患者危险分层的价值分析[J]. 临床医学工程, 2018, 25(11): 1569-1570. https://www.cnki.com.cn/Article/CJFDTOTAL-YBQJ201811072.htm

Catalog

    Article views (362) PDF downloads (21) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return