Significance of screening cervical lesionsby cytology examination combined with human papilloma virus genotyping

  Objective  To explore the relationship between cervical cytology(TCT), human papillomavirus(HPV) tests and histopathology by cervical biopsy.

  Methods  The relationship between TCT, HPV Results and advanced histopathological changes confirmed by cervical biopsy in 130 women.

  Results  Out of theses patients, TCT tests revealed four results: normal cells, atypicalsquamous cells of undetermined significance(ASCUS), low-grade squamous intraepithelial lesion(LSIL), high-grade squamous intraepithelial lesion(HSIL), and the positive rates of HSIL were 15.8%, 22.2%, 43.8%, and 100.0%, respectively (P < 0.05).Taking lesions above ASCUS as positive standard of TCT screening, the sensitivity and specificity of HSIL were 84.2% and 34.8%, respectively.The positive rates of high grade cervical lesions with negative and positive HPV Results were 6.7% and 34.0%, respectively (P < 0.05).The sensitivity of high grade cervical lesions was 94.1%and the specificity was 31.1% in HPV positive screening.The positive rates of high-level lesions were 0%, 16.7%, and 42.1%, respectively, in high grade cervical lesions with double negative, single positive, and double positive Results by TCT combined with HPV tests(P < 0.05).The sensitivity and specificity of TCT combined with HPV screening for high-level lesions was 84.2%, 52.2%, respectively.

  Conclusion  TCT and HPV in combination can improve specificity of high-level lesions screening.