Effect of self-designed Qingre Quyu Yishen Decoction combined with cyclophosphamide on early lupus nephritis

  Objective  To explore the clinical value of self-designed Qingre Quyu Yishen Decoction combined with cyclophosphamide in the treatment of early lupus nephritis.

  Methods  A total of 100 early lupus nephritis patients in our hospital were select as research objects. According to the random number expression method, they were divided into observation group (50 cases) and the reference group (50 cases). Patients of two groups were all treated with cyclophosphamide, observation group added self-designed Qingre Quyu Yishen Decoction. Treatment efficacy, the changes of symptoms and adverse reactions were observed.

  Results  The total effectiverate of treatment in the observation group and the reference group was 94.00%and 80.00%, respectively, a significant difference between the two groups was observed(P < 0.05). Before treatment, the serum creatinine, 24 h urine protein concentration, blood uric acid and serum urea nitrogen levels of the two groups showed no significant difference (P>0.05), and were significantly better in observation group after treatment than the reference group (P < 0.05). The systemic lupus erythematosus disease activity(SLEDAI) score and TCM symptom score in the observation group were significantly lower than that in the reference group, and the SF-36 score was significantly higher than that in the reference group (P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the reference group (P < 0.05).

  Conclusion  Qingre Quyu Yishen Decoction combined with cyclophosphamide in the treatment of early lupus nephritis has definite effect, which can promote renal function and clinical symptoms, and improve patients′quality of life. At the same time, it has high safety in clinic.