Objective To explore the changes of serum levels of creatine kinase isoenzyme (CK-MB), α-hydroxybutyrate dehydrogenase (α-HBDH) and prealbumin after treatment of neonatal septic shock and their clinical significance.
Methods A total of 120 neonates with septic shock admitted to the hospital were selected as case group, and another 40 normal healthy neonates who were delivered in the hospital during the same period were selected as control group. Serum levels of CK-MB, α-HBDH and PA before treatment and after 2 weeks of treatment were monitored in case group, and were determined after admission in control group. The relationship between changes of serum levels of CK-MB, α-HBDH, PA and changes of disease in children with septic shock were explored, and their clinical significance were analyzed.
Results The serum levels of CK-MB and α-HBDH in case group were significantly higher after admission while the PA level was lower than that in control group (P < 0.05). Serum levels of CK-MB and α-HBDH in children with mild sepsis shock after admission were higher while serum PA level was lower than those with severe sepsis shock (P < 0.05). The levels of CK-MB and α-HBDH were decreased and the level of PA was increased in case group after 2 weeks of treatment, and there was significant difference compared with before treatment (P < 0.05). The CK-MB recovery time, α-HBDH recovery time, PA recovery time and hospital stay in children with severe sepsis shock were longer than those with mild sepsis shock (P < 0.05).
Conclusion The levels of CK-MB and α-HBDH are obviously up-regulated and the PA level is decreased in neonates with septic shock. With the progression of septic shock, serum CK-MB and α-HBDH levels are gradually increased and PA level gradually decreased. The changes of aboveindexes are closely related to the treatment response.
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