Auxiliary effect of oral vitamin D in the treatmentof children with bronchial asthma

  Objective  To evaluate the effect of oral vitamin D in the treatment of children with bronchial asthma.

  Methods  A total of 200 children with bronchial asthma enrolled in the hospital were divided into two groups according to the stratified randomized principle. The control group(n=100) were treated with budesonide, and the observation group(n=100) were treated with oral vitamin D. The improvement of lung function and asthma symptoms between the two groups after treatment were compared.

  Results  The levels of interleukin-2(IL-2) and tumor necrosis factor-α(TNF-α) in the observation group were lower than those in the control group (P < 0.05). The effective rate of asthma control was higher than that that in the control group (P < 0.05). After treatment, forced expiratory volume in one second(FEV₁), peak expiratory flow(PEF) and forced ratio of expiratory volume in one second to forced vital capacity(FEV₁/FVC) in the observation group had better improvement than that of the control group (P < 0.05). The time in relief of shortness of breath, the disappearance of wheezing, the disappearance of arpeggio and cough were shorter than the control group (P < 0.05).

  Conclusion  Vitamin D in the treatment of bronchial asthma can effectively improve the symptoms and lung function of children.