Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance

  Objective  To investigate the expression of super conservative RNA uc.189 in colorectal cancer and its clinical significance.

  Methods  Total RNA was extracted from 130 pairs of colorectal cancer tissues and adjacent normal colorectal tissues. The RNA expression of uc.189 was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), and the relationship between uc.189 expression and clinic pathological parameters was analyzed.

  Results  The RNA expression of uc.189 was significantly higher in colorectal cancer tissues than that in adjacent normal tissues (P < 0.05). The high expression of uc.189 in colorectal cancer was associated with the pathological grading, lymphatic metastasis and TNM staging (P < 0.05).

  Conclusion  The uc.189 is associated with the occurrence and development of colorectal cancer.