Value of soluble urokinase type plasminogen activator receptor combined with procalcitonin detection in early diagnosis and prognosis of ventilator-associated pneumonia

  Objective  To investigate the value of soluble urokinase plasminogen activator receptor (suPAR) combined with procalcitonin (PCT) detection in early diagnosis and prognosis of ventilator-associated pneumonia(VAP).

  Methods  A total of 60 patients with VAP(observation group) were divided into survival group (n=32) and death group (28) according to the different prognosis. At the same period, 30 patients with mechanical ventilation without VAP were selected as the control group. The expression levels of serum su-PAR and PCT of the observation group and control group before and after mechanical ventilation were detected by using enzyme-linked immunosorbent(ELISA). At the same time, their levels in the survival group and death group at the 1, 3, 5, 7 days after treatment were also detected. The value of serum su-PAR combined with PCT detection in diagnosis and predicting survival of patients were analyzed by the receiver-operating characteristic curve (ROC).

  Results  There were no significant differences in the levels of serum su-PAR and PCT between the two groups before mechanical ventilation and in the control group before and after mechanical ventilation(P>0.05). The expression levels of serum su-PAR and PCT of the observation group after mechanical ventilation were significantly higher than those of before mechanical ventilation and the control group after mechanical ventilation(P < 0.05). The expression levels of serum su-PAR and PCT of the death group at 1, 3, 5 and 7 day of the treatment were significantly higher than those of the survival group (P < 0.05), and their levels were significantly higher with the time extension of the treatment (P < 0.05). Meanwhile, their expression levels of survival group reached a peak on the 5th day of treatment, while decreased significantly on the 7th day (P < 0.05). The value of serum su-PAR combined with PCT in the early diagnosis of VAP and the prediction of VAP patient survival was better than that of single indicator detection.

  Conclusion  The detection of serum su-PAR combined with PCT has a high value in early diagnosis and prognosis of VAP.