Changes of vascular endothelial damage and anticoagulation function in patients with arthropathic psoriasis

Objective To study endothelial cell damage and changes of parameters related to coagulation and the anticoagulation function in patients with arthropathic psoriasis.Methods A total of 31 psoriasis vulgaris patients,29 arthropathic psoriasis patients and 60 normal controls were enrolled.Coagulation analyzer ALC 9000 was used to measure the parameters related to endothelial damage,coagulation and anticoagulation system in these patients and controls.The correlation between PASI and the tested parameters was assessed.Results Compared with the normal controls,decreased atithrombin activity as well as protein C activity and antigen were observed in 31 psoriasis vulgaris patients and 29 psoriasis arthropathic patients,whereas increased levels of plasminogen activator inhibitor-1 and vW factor were found in these patients.Patients with arthropathic psoriasis had higher levels of plasminogen activator inhibitor-1 and vW factor but a lower level of atithrombin activity as well as protein C activity and antigen than those with psoriasis vulgaris.There was no correlation between PASI and any of the tested parameters.Conclusion There is a more serious damage of endothelial cell in patients with arthropathic psoriasis than psoriasis vulgaris patients,which may lead to the attenuation of anticoagulation function and fibrinolysis activity.Arthropathic psoriasis patients may have a high risk of suffering cardiovascular disease under the background of the inflammation.