Correlation between serum levels of interleukins and concomitant wheezing in children with mycoplasma pneumoniae pneumonia

Objective To study and analyze the correlation between serum levels of interleukins and concomitant wheezing in children with mycoplasma pneumoniae pneumonia (MPP).Methods A total of 136 children with MPP were selected as the case group.The children were divided into the wheezing group (n =59) and the non-wheezing group (n =77).The children in the wheezing group were divided into the acute phase group (n =26) and the remission phase group (n =33) according to the condition of the disease.Sixty healthy children were selected as the control group.The serum interleukin-4 (IL-4),interleukin-5 (IL-5),interleukin-13 (IL-13) levels were detected and compared among all the groups.Results There were significant differences in the serum IL-4,IL-5,IL-13 levels among the wheezing group,the non-wheezing group and the control group (F =16.332,112.369,96.411,P ＜ 0.05).There were significant differences in the serum IL-4,IL-5,IL-13 levels among the acute phase group,the remission phase group and the control group (F =24.058,174.212,143.720,P ＜ 0.05).In the case group,the serum IL-4 level was positively correlated with the IL-5 level (P ＜ 0.05),and there were no correlations between the IL-4 level and the IL-13 level,the IL-5 level and the IL-13 level (P ＞ 0.05).Conclusion The serum expression of IL-4,IL-5 and IL-13 increase in patients with MPP.