The clinical observation of preinjection dezocine during induction of general anesthesia with sufentanil on different injection speed on induced cough reflex

Objective To observe preinjection of dezocine on different injection speed on induced cough response.Methods 200 undergoing general anesthesia operation patients with ASA Ⅰ~Ⅱ were randomly divided into four groups,each group with 50 people.Ⅰ,Ⅱ (experi-mental group)were injected before induction of intravenous dezocine 0.1 mg /kg (diluted with nor-mal saline to 5 mL),Ⅲ,Ⅳ (control group)were injected with physiological saline 5 mL.General anesthesia were inducted after 5 minutes in each group,including Ⅰ,Ⅲ group as fast injection group,infusion of sufentanil 0.5 μg /kg with 5s injection time;Ⅱ,Ⅳ group was slow injection group with infusion of sufentanil 0.5μg /kg,injection time was 30 s.Incidence and intensity of in-fusion of sufentanil after 2 min cough were observed and recorded.The changes of SBP,DBP and HR before and after tracheal intubation were record.Results Difference in SBP,DBP and HR was no significant before and after intubation in four groups (P >0.05).The incidence of cough inⅠ,Ⅱ group was significantly more than the Ⅳ group (P <0.01),the difference was statistically significant since the incidence of cough in IV group was lower than that in group Ⅲ (P <0.05). Conclusion Sufentanil injection speed can influence the occurrence of cough response,and pre-implantation using dezocine can effectively reduce the different injection speed of sufentanil induced incidence of cough,effect in slow infusion group was obvious.So it is a good way to ensure stablity during anesthesia induction.