Curative effect of ganglioside on acute intracerebralhemorrhage interleukin-1β,(AICH)and its influence on serum IL-6 and IL-8 levels

Objective To discuss curative effect of Ganglioside on acute intracerebral hem-orrhage (AICH)and its influence on serum interleukin-1β,IL-6 and IL-8 levels.Methods 76 pa-tients with AICH were divided into observation group and control group by random digital table method with 38 patients in each group.The patients in two groups were given routine medical treatment,such as reducing intracranial pressure and blood pressure,hemostasis,anti-infection, brain cells nutrition and so on.The patients in observation group were additionally given 60 mg Ganglioside by intravenous infusion for once a day,while the patients in control group were addi-tionally given 0.5 g Citicoline Sodium Injection by intravenous infusion,once a day for 10 days. The changes of serum IL-1β,IL-6 and IL-8 levels of patients in two groups before and after medi-cal treatment were observed,and the clinical curative effect and drug adverse reaction (DAR)were compared as well.Results After 10 days′medical treatment,the serum IL-1β,IL-6 and IL-8 lev-els of patients in two groups obviously declined than before (P <0.05 and P <0.01),and the de-clining rate in observation group was much higher than that in control group (P <0.05).The total clinical efficiency of patients in observation group was much higher than that in control group (94.74% vs.78.95%)(χ2=4.15,P <0.05).Adverse effect appeared in 2 and 4 patients in control group and observation group respectively during the medical treatment with light symptom and no serious DAR.After comparing the occurrence rates of adverse effect of patients in two groups,there was no statistical differences (χ2=0.18,P >0.05).Conclusion Ganglioside has favorable curative effect on AICH with high security,whose mechanism of action may inhibit lo-cal inflammatory response to protect the secondary brain injury after intracerebral hemorrhage by reducing the serum serum IL-1β,IL-6 and IL-8 levels.