Application of mifepristone combined with rivanol in midtrimester induction of labor

Objective To explore the clinical efficacy of mifepristone combined with rivanol in induction of labor.Methods 100 patients requiring induction of labor were randomly divided in-to experimental group and control group with 50 patients in each group.The control group was giv-en intra-amniotic injection of 75 mg rivanol,while the patients in the experimental group orally took 75 mg mifepristone under fasting condition based on the therapy in the control group,and took another 75 mg after 24 hours.The score of cervical Bishop,onset time of uterus contraction,time to eliminate the fetus,total stage of labor,abortion effect,amount of postpartum hemorrhage and side effects were all observed in the two groups.Results After administration of the drugs,the score of cervical Bishop in the experimental group was markedly higher than that in the control group,while onset time of contraction,time to eliminate the fetus,total stage of labor and amount of postpartum hemorrhage were obviously less than that in the control group.The response rate of induction of labor in experimental group (1 0 0 % )was higher than that in the control group (92.0%),the difference was statistically significant.Conclusion Application of mifepristone com-bined with rivanol to terminate the pregnancy can effectively soften the cervix,shorten the time of delivery of baby,reduce patients′pain and relevant complications and ameliorate postpartum recov-ery,so it is worthy of clinically popularization.