Safety and efficacy of low dose sulfentanyl in labor analgesia

Objective To explore the effect of low dose sulfentanyl on labor analgesia. Methods 90 puerperas were randomly divided into observation group,control group I and control group Ⅱ,30 cases in each group.Sulfentanyl was used for labor analgesia in all the groups.The dose of sulfentanyl in the control group Ⅰ,the observation group and control group Ⅱ were 3 μg, 5 μg and 7μg respectively.Indexes such as analgesic efficacy,maternal birth outcomes,adverse re-actions and neonatal state were compared among three groups.Results The onset time of analge-sia in the control group Ⅰ was significantly longer than that in the observation group or the control group Ⅱ (P <0.05),while the first agent duration was significantly shorter than that in the ob-servation group or the control group Ⅱ (P <0.05);before the analgesia,there was no significant difference of VAS score among three groups (P >0.05);at the time of 30 and 60 minutes after analgesia,the VAS score of the control group I was significantly higher than that of the other two groups (P <0.05);there were no significant differences of the vaginal delivery rate,assistant vaginal delivery rate and cesarean section rate among the three groups (P >0.05);the incidence rates of the adverse reactions such as pruritus,nausea and vomiting,lethargy and fetal heart changes of the women in the control group Ⅰ and the observation group were significantly lower than those in the control group Ⅱ (P <0.05);the Apgar scores of the neonates in the control group Ⅰ and the observation group were significantly higher than that in the control group Ⅱ (P<0.05).Conclusion Efficacy of high or low dose sulfentanyl for labor analgesia is similar,while a very low dose sulfentanyl can not achieve the desired results.Compared with a high dose sulfen-tanyl,the adverse reactions probability induced by a low dose sufentanil is low and the neonatal state is better.