Objective To observe the effect of nursing intervention based on concept of enhanced recovery after surgery (ERAS) in patients with advanced rectal cancer after cytoreductive surgery combined with intraperitoneal perfusion chemotherapy.

Methods A total of 124 patients with intraperitoneal chemotherapy for rectal cancer were selected as study subjects, and randomly divided into observation group (n=62) and control group (n=62). The control group was treated with routine nursing intervention, and the observation group was treated with nursing intervention based on ERAS concept. Visual Analogue Scale (VAS) scores were compared between the two groups. The scores of Self Rating Anxiety Scale (SAS), Self Rating Depression Scale (SDS) and Quality of Life Questionary-Core 30 (QOL-C30) before and after intervention were compared between the two groups. The occurrence of adverse reactions and nursing satisfaction were compared between the two groups.

Results The VAS score of the observation group was significantly lower than that of the control group at the 2nd and 3rd chemotherapy (P<0.05). After intervention, SAS score and SDS score in two groups were significantly lower than before intervention, and the observation group was significantly lower than the control group (P<0.05). After intervention, the QOL-C30 scores of body function, role function, emotional function, cognitive function and social function in two groups were significantly higher than before intervention, and the observation group was significantly higher than the control group (P<0.05); symptom score of QOL-C30 in two groups was significantly lower than before intervention, and the observation group was significantly lower than the control group (P<0.05). After intervention, the incidence of adverse reactions in the observation group was 56.45%, which was significantly lower than 77.42% in the control group (P<0.05). After intervention, the nursing satisfaction score of the observation group was significantly higher than that of the control group (P<0.05).

Conclusion Nursing intervention based on ERAS concept can effectively relieve pain and adverse emotions in patients with advanced rectal cancer undergoing cytoreductive surgery combined with intraperitoneal perfusion chemotherapy, reduce the incidence of adverse reactions, and improve quality of life, with high nursing satisfaction.