Abstract: Objective:To evaluate the signifcance of epidermal growth factor receptor(EGFR) expression in human transitional cell carcinoma of bladder(BTCC).Methods:The expression of EGFR was detected by standard ABC immunohistochemical technique in 33 paraffin-embedded tissue specimens of BTCC compared with 12 normal ones.Results:All normal transitional cells were negatively stained and all neoplastic cells were positively stained .Fisher's accurate analysis showed that moderately or strongly positive espression of EGFR in tumor cells closely correlated with different pathological grades(P0 05),clinical stages(P0 05),number of lesions(P0 05)and postoperative reccurance (P0 05).Conclusion:It was suggested that over expression of EGFR closely correlated with biological behaviour of BTCC and it played a very important role on the process of occurence and progress.