Abstract: The effects of pressure on vascular tissue structure and function have been observed.The technique for" welding" vascular tissue as an alternative t0 suture repair has been develoPed. A0rtaswere removed from white rabbits and strips of aorta were b0nded to each other (intima-to -intima) bysubjectlng them to compression on a epecially constructed fitting designed to exert uniform pressure over anarea 0f lcm'- Pressures were maintained at 10- 300kg for time periods ranging form 1 to 60 minutes.200kg applied f0r times ranging form 5 to 6O minutes pr0foudly affects tensile strength- The applicati0n ofpressure for 6O minutes results in the f0rmation of relatively large am0unts of OHP in compressed tissue-The most likely force responsible f0r pressure-mediated tissue b0nding is increased pressure. Pressure ac-celerates OHP formati0n by 0rders 0f magnitude. A novel appr0ach for n vascular tissue welding" is de-scribed.