Objective To analyze the current research status, hotspots, and trends in the field of mechanical ventilation weaning.

Methods Literatures in the field of mechanical ventilation weaning were retrieved from the Web of Science Core Collection, PubMed, China National Knowledge Infrastructure (CNKI), and Wanfang Data Knowledge Platform from January 1, 2010 to November 27, 2024. CiteSpace software was used to analyze the research status and future trends.

Results A total of 705 English and 494 Chinese eligible articles were included in this study. The author with the most publications was Laurent Brochard (14 articles). Research hotspots focused on mechanical ventilation, weaning, non-invasive ventilation, respiratory failure, etc. New research hotspots have shifted towards mechanical ventilation weaning failure, weaning complications, and prolonged weaning.

Conclusion Further research is needed on weaning failure, complications, and prolonged weaning, particularly in the direction of invasive-high-flow oxygen therapy sequential therapy, which will help optimize clinical treatment plans and reduce patients'suffering and economic burdens.