针刺放血法联合通腑化痰汤对出血性中风患者意识恢复及脑电图的影响

Effects of acupuncture bloodletting combined with Tongfu Huatan Decoction on consciousness recovery and electroencephalogram in patients with hemorrhagic stroke

  • 摘要:
    目的 探讨针刺放血法联合通腑化痰汤对出血性中风患者意识恢复时间及脑电图的影响。
    方法 随机将出血性中风患者100例分为对照组和研究组,每组50例。对照组口服通腑化痰汤治疗,研究组联合采用针刺放血法与通腑化痰汤治疗。分析2组患者治疗前后的血清学指标氨基末端脑钠肽前体(NT-proBNP)、中枢神经特异性蛋白(S100β)、水通道蛋白1 (AQP-1)和促血管生成素1(Ang-1)、意识障碍评分格拉斯哥昏迷量表(GCS)、全面无反应性量表(FOUR)、改良国际昏迷恢复量表(CRS-R)、脑电图改善情况、脑血流灌注指标脑血流量(CBF)、脑血容量(CBV)、意识恢复时间以及不良反应、并发症发生情况。
    结果 治疗前, 2组各指标差异无统计学意义(P>0.05)。治疗后, 2组血清中的NT-proBNP、S100β、AQP-1、Ang-1水平均降低,且研究组低于对照组,差异有统计学意义(P < 0.05); 2组GCS、FOUR、CRS-R评分、CBF、CBV水平均升高,研究组升高更显著,差异有统计学意义(P < 0.05); 研究组的脑电图改善情况优于对照组,且意识恢复时间更短,差异有统计学意义(P < 0.05), 但2组不良反应及并发症差异无统计学意义(P>0.05)。
    结论 针刺放血法联合通腑化痰汤能改善出血性中风患者脑部功能,减轻脑部损伤,缩短意识恢复时间。

     

    Abstract:
    Objective To explore the effects of acupuncture bloodletting combined with Tongfu Huatan Decoction on consciousness recovery time and electroencephalogram in patients with hemorrhagic stroke.
    Methods A total of 100 patients with hemorrhagic stroke were randomly divided into control group and study group, with 50 patients in each group. The control group was treated with oral administration of Tongfu Huatan Decoction, while the study group received combined treatment of acupuncture bloodletting and Tongfu Huatan Decoction. Serological indicatorsN-terminal pro-brain natriuretic peptide (NT-proBNP), central nervous system-specific protein (S100β), aquaporin (AQP-1), and angiogenin 1 (Ang-1), consciousness disturbance scoresGlasgow Coma Scale (GCS), Full Outline of Unresponsiveness (FOUR), and Coma Recovery Scale-revised (CRS-R), electroencephalogram improvement, cerebral blood perfusion indicatorscerebral blood flow (CBF), cerebral blood volume (CBV), consciousness recovery time, and the occurrence of adverse reactions and complications were analyzed before and after treatment in both groups.
    Results Before treatment, there were no statistically significant differences in all indicators in two groups (P>0.05). After treatment, the study group showed decreased levels of serum NT-proBNP, S100β, AQP-1, and Ang-1 in two groups, and showed significant differences between two groups (P < 0.05). The scores of GCS, FOUR, and CRS-R, as well as the levels of CBF and CBV increased in two groups, with more significant increase in the study group (P < 0.05). The improvement of electroencephalogram in the study group was significantly better, and the consciousness recovery time was shorter than that in the control group (P < 0.05). However, there were no statistically significant differences in adverse reactions and complications between the two groups (P>0.05).
    Conclusion Acupuncture bloodletting combined with Tongfu Huatan Decoction can enhance cerebral function, reduce cerebral damage, and shorten consciousness recovery time in patients with hemorrhagic stroke.

     

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