Abstract: This study retrospectively analyzed the literature on the prevention and management of complications associated with hyaluronic acid injectable fillers. Starting with the physicochemical properties and pharmacological research of hyaluronic acid, this review summarized its clinical application in facial injection, complications, and corresponding treatment modalities. Clinicians administering hyaluronic acid injections should attach great importance to potential risks, adopt targeted preventive measures, and promptly address issues to maximize the avoidance of severe complications.