Abstract:
Objective To explore the traditional Chinese medicine (TCM) syndrome characteristics and medication patterns of cerebral small vessel disease (CSVD) using data mining techniques.
Methods Clinical research literature on TCM treatment of CSVD, published from the establishment of the database to September 1, 2024, was retrieved from the China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases. Analyses were conducted on syndromes, drug frequencies, properties, flavors, and meridian tropisms. Data mining was performed using R4.4.1 software to explore associations, correlations, and clustering of TCM herbs, aiming to elucidate medication patterns in CSVD treatment.
Results A total of 60 prescription formulas for treating CSVD were screened, involving 142 TCM herbs with a total usage frequency of 1, 312 times. The top five most frequently used herbs were Chuanxiong, Danggui, Dilong, Huangqi, and Chishao. Herb properties were predominantly warm and cold; flavors were mainly pungent, bitter, and sweet; and meridian tropisms were primarily to the liver, spleen, and heart meridians. Twenty-nine strong association rules were identified, and association analysis revealed core herbal combinations centered around Chuanxiong, Chishao, and Danggui. Clustering analysis yielded five herbal combinations.
Conclusion CSVD is characterized by a deficiency in essence and excess in superficiality. Treatment should focus on tonifying deficiencies and eliminating excesses, combining both tonification and purgation methods. Medication patterns predominantly involve herbs for promoting blood circulation and removing blood stasis, often combined with herbs for nourishing the kidney and marrow, calming the liver and suppressing wind, and awakening the mind and opening the orifices.
下载: