慢性鼻窦炎发病机制及中医药防治研究进展

Research progress on pathogenesis as well as prevention and treatment of chronic rhinosinusitis with traditional chinese medicine

  • 摘要: 慢性鼻窦炎(CRS)是一种常见的鼻腔和鼻窦黏膜长期炎症, 涉及多种发病机制,如感染、过敏反应及免疫异常等。CRS主要症状包括鼻塞、流涕、嗅觉减退,严重影响患者生活质量。寻找安全且有效的长期治疗方法是管理CRS的关键。中医药治疗CRS历史悠久,以其高安全性和低复发率受到关注。中医认为CRS多由风寒湿邪侵袭、肺经蕴热或脾胃虚弱所致,采用中药内服、滴鼻、针灸等多种疗法调整机体平衡,以达到治疗目的。本文通过综合分析近年来国内外文献,综述CRS的发病机制及中医药治疗的研究进展,特别强调中药活性成分的作用及其机制,旨在为CRS的预防与治疗提供科学依据和技术支持。

     

    Abstract: Chronic rhinosinusitis (CRS) is a common chronic inflammation of nasal cavity and sinus mucosa, involving multiple pathogenesis mechanisms such as infection, allergic reactions, and immune abnormalities. Its main symptoms include nasal obstruction, rhinorrhea, and hyposmia, significantly affecting patients' quality of life. Seeking safe and effective long-term treatment methods is crucial for managing CRS. Traditional Chinese medicine (TCM) has a long history of treating CRS and has gained attention due to its profound theoretical basis, high safety, and low recurrence rate. According to TCM, CRS is mostly caused by the invasion of wind-cold-damp pathogens, heat accumulation in the Lung meridian, or spleen-stomach weakness. Various therapies such as oral administration of Chinese herbal medicines, nasal drops, acupuncture, and moxibustion are employed to adjust the body's balance and achieve therapeutic goals. This article comprehensively analyzed recent domestic and international literature and reviewed the research progress on pathogenesis of CRS and its treatment with TCM, with particular emphasis on roles and mechanisms of active ingredients in Chinese herbal medicines. The aim of the study is to provide scientific evidence and technical support for prevention and treatment of CRS.

     

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