Objective To explore the anti-infective therapeutic regimen for patients with multiple site infections after neurosurgery.

Methods Clinical pharmacists specializing in anti-infective field were fully involved in formulation of personalized anti-infective regimens at various stages when a patient with cerebral hemorrhage developed catheter-related bloodstream infection (CRBSI), surgical site infection (SSI), and aspiration pneumonia following neurosurgery.

Results All suggestions made by clinical pharmacists were adopted by clinicians. The patient′s postoperative multiple site infections were effectively controlled, and the patient was successfully transferred out of the neurosurgery ICU.

Conclusion Patients are prone to multiple site infections after neurosurgery. Clinical pharmacists specializing in anti-infective field should actively leverage their professional expertise to assist clinicians in identifying possible infection sites and pathogens as early as possible. They should also formulate appropriateregimens based on the patient′s pathophysiological characteristics, severity of infection, and pharmacokinetic/pharmacodynamic properties of the drugs, and provide comprehensive pharmaceutical care, dynamically adjust the regimen, and improve the prognosis.