Abstract: Objective To investigate the surgical nursing coordination methods in the modified outflow tract trans-sternal approach for left ventricular assist device implantation. Methods A retrospective analysis was conducted on the clinical data of 3 patients who underwent modified outflow tract trans-sternal LVAD implantation at our hospital. Results All 3 surgeries were successfully completed. The mean operative time was (311.7±34.1) minutes, and the mean blood loss was (383.3±28.9) mL. Patients were discharged after (48.3±16.8) days postoperatively in average. No significant complications occurred, and the postoperative condition of patients was stable. Conclusion The modified outflow tract for left ventricular assist device implantation provides more stable hemodynamics for patients. Compared with the traditional median sternotomy, the trans-sternal approach not only facilitates the dissection of chest wall tissues and better access to the surgical field but also offers the advantages of smaller incisions and faster recovery. Proficient surgical operation techniques and skilled surgical coordination are crucial for the success of this procedure.