Abstract: Objective To explore the application of bundled nursing care for recurrent obstructive esophageal cancer treated by photodynamic therapy. Methods Thirty patients with recurrent obstructive esophageal cancer were administered with photosensitizer hematoporphyrin derivative injection. After 24 hours, an optical fiber was introduced under endoscopic guidance, and 630 nm laser was used to irradiate the tumor locally. The degree of relief in dysphagia, improvement in performance status, changes in body mass index, and treatment-related adverse reactions were recorded. Bundled nursing strategies were implemented, including preoperative assessment, education, preparation, postoperative positioning, observation, prevention of complications, and light protection measures. Results After treatment, the median diameter of the narrowest esophageal lesion was increased (8.92±0.64) mm versus (4.77±0.60) mm, the Karnofsky Performance Status (KPS) score was improved (77.69±5.99) versus (84.62±6.60), BMI was increased (17.17±1.66) kg/m² versus (18.08±1.60) kg/m², and the Stooler dysphagia grade was decreased compared with treatment before. The main treatment-related adverse reactions were retrosternal pain and fever. Conclusion Photodynamic therapy for recurrent obstructive esophageal cancer has a rapid onset of action and mild adverse reactions, and ensures the smooth implementation of PDT and patients'safety.