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尿肝脏型脂肪酸结合蛋白、血清半乳糖凝集素3与痛风患者早期肾功能损伤的相关性研究

Relationships of urinary liver-type fatty acid-binding protein and serum galectin-3 with early renal dysfunction in gout patients

    摘要
  • 摘要:
    目的 探讨尿肝脏型脂肪酸结合蛋白(L-FABP)、血清半乳糖凝集素-3(Gal-3)与痛风患者早期肾功能损伤的关系。
    方法 选取2022年1月—2023年12月本院收治的痛风患者124例为痛风组，根据尿白蛋白与肌酐比值(UACR)分为无肾损伤组42例和早期肾损伤组82例; 另选取同期在本院体检的健康志愿者40例作为对照组。检测所有受试者的尿素氮、肌酐、胱抑素C、尿L-FABP、血清Gal-3水平。采用受试者操作特征(ROC)曲线分析尿L-FABP、血清Gal-3对痛风患者早期肾功能损伤的评估价值。
    结果 痛风组胱抑素C、尿L-FABP、血清Gal-3水平高于对照组，差异有统计学意义(P < 0.05)。早期肾损伤组胱抑素C、尿L-FABP、血清Gal-3水平高于无肾损伤组，差异有统计学意义(P < 0.05)。Pearson分析显示，痛风患者尿L-FABP水平与UACR、胱抑素C、血清Gal-3均呈正相关(P < 0.05)，痛风患者血清Gal-3水平与UACR、胱抑素C、尿L-FABP均呈正相关(P < 0.05)。ROC曲线显示，尿L-FABP、血清Gal-3对痛风患者早期肾功能损伤的评估价值较高，曲线下面积分别为0.804(95%CI: 0.726~0.882)、0.781(95%CI: 0.697~0.866), 二者联合的曲线下面积为0.923(95%CI: 0.874~0.972)。
    结论 痛风患者尿L-FABP、血清Gal-3均异常升高，其表达水平与患者早期肾功能损伤密切相关。尿L-FABP联合血清Gal-3评估痛风患者早期肾功能损伤的价值较高。

     

    Abstract:
    Objective To investigate the relationships of urinary liver-type fatty acid-binding protein (L-FABP) and serum galectin-3 (Gal-3) with early renal dysfunction in gout patients.
    Methods A total of 124 gout patients in the hospital from January 2022 to December 2023 were selected as gout group, and they were divided into non-renal injury group with 42 cases and early renal injury group with 82 cases according to the urinary albumin-to-creatinine ratio (UACR). Additionally, 40 healthy volunteers with physical examinations in the hospital in the same period were selected as control group. The levels of urea nitrogen, creatinine, cystatin C, urinary L-FABP, and serum Gal-3 were measured in all participants. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of urinary L-FABP and serum Gal-3 for early renal dysfunction in gout patients.
    Results The levels of cystatin C, urinary L-FABP, and serum Gal-3 in the gout group were significantly higher than those in the control group (P < 0.05). The levels of cystatin C, urinary L-FABP, and serum Gal-3 in the early renal injury group were significantly higher than those in the non-renal injury group (P < 0.05). Pearson analysis showed that urinary L-FABP level in gout patients was significantly positively correlated with UACR, cystatin C, and serum Gal-3 (P < 0.05), and serum Gal-3 level in gout patients was significantly positively correlated with UACR, cystatin C, and urinary L-FABP (P < 0.05). ROC curve analysis indicated that urinary L-FABP and serum Gal-3 had high diagnostic values for assessing early renal dysfunction in gout patients, with areas under the curve (AUCs) of 0.804 (95%CI, 0.726 to 0.882) and 0.781 (95%CI, 0.697 to 0.866) respectively. The AUC for the combination of urinary L-FABP and serum Gal-3 was 0.923 (95%CI, 0.874 to 0.972).
    Conclusion The levels of urinary L-FABP and serum Gal-3 are abnormally elevated in gout patients, and their expression levels are closely related to early renal dysfunction. The combination of urinary L-FABP and serum Gal-3 has a high diagnostic value for early renal dysfunction in gout patients.

     

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