高级检索

功能性消化不良患儿血清单核细胞趋化蛋白-1和前列腺素E2水平变化及临床意义

Changes and clinical significance of serum monocyte chemoattractant protein-1 and prostaglandin E2 levels in children with functional dyspepsia

    摘要
  • 摘要:
    目的 探讨功能性消化不良(FD)患儿血清单核细胞趋化蛋白-1(MCP-1)、前列腺素E2(PGE2)水平变化及临床意义。
    方法 回顾性纳入2022年10月—2023年10月收治的89例FD患儿作为FD组, 另选取同期健康儿童91例作为对照组。根据FD患儿病情严重程度将其分为轻度组36例、中度组33例、重度组20例。采用酶联免疫吸附法(ELISA)检测血清MCP-1、PGE2水平。采用整体症状量表(GOSS)评分对患儿病情进行评估，并检测所有患儿胃排空情况。采用皮尔逊(Pearson)及斯皮尔曼(Spearman)相关性分析探讨血清MCP-1、PGE2水平与胃半排空情况和FD症状评分的相关性。
    结果 FD组血清MCP-1水平高于对照组, PGE2水平低于对照组，差异有统计学意义(P < 0.05)。重度组患儿血清MCP-1水平高于中度组与轻度组, PGE2水平低于中度组与轻度组，中度组血清MCP-1水平高于轻度组, PGE2水平低于轻度组，差异均有统计学意义(P < 0.05)。FD组患儿胃半排空时间与餐后2 h残留率均高于对照组，差异有统计学意义(P < 0.05)。FD患儿血清MCP-1与胃半排空时间、餐后2 h残留率呈正相关(P < 0.05), 血清PGE2与胃排空时间、餐后2 h残留率呈负相关(P < 0.05)。FD患儿血清MCP-1与上腹烧灼感、早饱感、嗳气、上腹痛及GOSS总分呈正相关(r=0.611、0.509、0.504、0.491、0.513, P < 0.05), PGE2与上腹烧灼感、早饱感、嗳气、上腹痛、反酸及GOSS总分呈负相关(r=-0.516、-0.561、-0.493、-0.533、-0.497、-0.482, P < 0.05)。
    结论 FD患儿血清MCP-1升高, PGE2降低, MCP-1、PGE2水平与病情严重程度、胃排空情况、FD部分症状密切相关。

     

    Abstract:
    Objective To investigate the changes and clinical significance of serum monocyte chemoattractant protein-1 (MCP-1) and prostaglandin E2 (PGE2) levels in children with functional dyspepsia (FD).
    Methods A retrospective study was conducted to enroll 89 FD children admitted from October 2022 to October 2023 as FD group, and 91 healthy children in the same period were selected as control group. The FD group was further divided into mild group (n=36), moderate group (n=33), and severe group (n=20) based on the severity of the disease. The serum levels of MCP-1 and PGE2 were detected by enzyme-linked immunosorbent assay (ELISA). The severity of the disease was assessed by the Global Overall Symptom Score (GOSS), and gastric emptying was evaluated in all the children. Pearson and Spearman correlation analyses were performed to explore the correlations of serum MCP-1 and PGE2 levels with gastric half-emptying time and FD symptom scores.
    Results The serum MCP-1 level in the FD group was significantly higher than that in the control group, while the PGE2level was significantly lower (P < 0.05). In the severe group, the serum MCP-1 level was significantly higher while the PGE2 level was significantly lower than that in the moderate and mild groups, and similar differences were significantly observed between the moderate and mild groups (P < 0.05). The gastric half-emptying time and postprandial 2-hour residual rate were significantly higher in the FD group than the control group (P < 0.05). Serum MCP-1 in FD children was positively correlated with gastric half-emptying time and postprandial 2-hour residual rate (P < 0.05), while serum PGE2 was negatively correlated with these parameters (P < 0.05). Serum MCP-1 in FD children was significantly positively correlated with upper abdominal burning sensation, early satiety, belching, upper abdominal pain, and the total GOSS score (r=0.611, 0.509, 0.504, 0.491, 0.513; P < 0.05), while PGE2 was significantly negatively correlated with upper abdominal burning sensation, early satiety, belching, upper abdominal pain, acid reflux, and GOSS total score (r=-0.516, -0.561, -0.493, -0.533, -0.497, -0.482; P < 0.05).
    Conclusion Elevated serum MCP-1 and decreased PGE2 levels in children with FD are closely related to the severity of the disease, gastric emptying, and some FD symptoms.

     

    • HTML全文
    • 参考文献(21)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回