早期口腔鳞状细胞癌浸润深度及侵袭模式在评估其复发及预后中的价值

储伟明; 郭爱军; 蒋记心; 戈杰; 薛雨; 管玮

doi:10.7619/jcmp.20240834

早期口腔鳞状细胞癌浸润深度及侵袭模式在评估其复发及预后中的价值

Value of invasion depth and invasion pattern in evaluating recurrence and prognosis of early oral squamous cell carcinoma

摘要

摘要:
目的探讨早期口腔鳞状细胞癌(OSCC)浸润深度(DOI)和侵袭模式(POI)在其复发预测和预后评价中的价值。
方法回顾性收集109例原发OSCC患者资料。临床资料分类变量的比较采用卡方检验。临床资料与肿瘤复发的相关性研究采用单因素和多因素Logistic回归分析。临床资料与患者总体生存期的相关性研究采用Cox回归分析。
结果单因素分析结果表明, POI、DOI和病理分级与早期OSCC复发及不良预后具有相关性。多因素Logistic回归分析显示, DOI为OSCC复发(OR=4.515, 95%CI: 1.283~15.894, P<0.05)及预后(HR=2.993, 95%CI: 1.225~7.317, P<0.05)的影响因素。OSCC的POI与DOI间有高度相关性。
结论 DOI≥5 mm被认为是早期OSCC复发和不良预后的相关因素。

Abstract:
Objective To investigate the value of depth of invasion (DOI) and pattern of invasion (POI) in predicting recurrence and evaluating prognosis of early oral squamous cell carcinoma (OSCC).
Methods Data of 109 patients with primary OSCC were retrospectively collected. The chi-square test was used to compare categorical variables of clinical data. Univariate and multivariate Logistic regression analyses were used to analyze the correlation between clinical data and tumor recurrence. Cox regression analysis was used to analyze the correlation between clinical data and overall survival of patients.
Results Univariate analysis showed that POI, DOI and pathological grade were correlated with recurrence and poor prognosis of early OSCC. Multivariate Logistic regression analysis indicated that DOI was an influencing factor for OSCC recurrence (OR=4.515, 95%CI, 1.283 to 15.894, P<0.05) and prognosis (HR=2.993, 95%CI, 1.225 to 7.317, P<0.05). There was a high correlation between POI and DOI of OSCC.
Conclusion DOI ≥5 mm is considered as a relevant factor for recurrence and poor prognosis of early OSCC.

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