前蛋白转化酶枯草溶菌素-kexin 9型抑制剂对血管内皮的保护作用机制研究进展

Research progress on the protective mechanism of proprotein convertase subtilisin/kexin type 9 inhibitors on vascular endothelium

摘要: 前蛋白转化酶枯草溶菌素-kexin9型抑制剂(PCSK9抑制剂)不仅具有良好的降脂作用, 还具有改善心血管结局、减轻氧化应激及改善血管内皮等多效性作用。近年来, PCSK9抑制剂的不断研发为心血管疾病治疗提供了新思路，本文就PCSK9抑制剂的多效性作用机制研究，尤其是对于血管内皮功能的作用机制研究予以综述。

Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors not only have good lipid-lowering effects, but also have pleiotropic effects such as improving cardiovascular outcomes, relieving anti-inflammation, relieving oxidative stress and improving vascular endothelium. In recent years, the continuous development of PCSK9 inhibitors provides new ideas for the treatment of cardiovascular diseases. This article reviewed the pleiotropic mechanisms of PCSK9 inhibitors, especially on vascular endothelial function.