Objective To investigate the impacts of drug administration processes on comfort, tolerability and adverse events in patients with chemotherapy for multiple myeloma.

Methods A total of 113 patients with chemotherapy for multiple myeloma were randomly divided into control group (n=56) and observation group (n=57). The control group was treated with conventional drug administration procedures, while the observation group was treated with bortezomib subcutaneously by an optimized drug administration process. Comfort level, tolerability, adverse events and satisfaction rate for injection were compared between the two groups before and after intervention.

Results After intervention, the observation group scored higher on the General Comfort Questionnaire (GCQ) for physiological dimension of (24.59±2.73), psychological dimension of (25.64±2.29), sociocultural dimension of (22.64±2.05), environmental of (11.79±1.37), and total score of (79.21±6.81) than (21.68±2.67), (22.05±2.16), (18.11±1.74), (9.42±1.46) and (63.52±6.34) respectively in the control group. Total chemotherapy course was (6.02±1.08) cycles in the observation group, which was less than (7.86±1.59) cycles in the control group, with a chemotherapy discontinuation rate of 8.77% versus 37.5%, and the full-dose and full-schedule chemotherapy completion rate of 96.49% versus to 82.14% between observation group and control group, and all the differences were statistical significant (P < 0.05). The overall incidence of liver-kidney function damage, thrombocytopenia, and peripheral neuropathy during medication administration was 3.51% in the observation group, which was significantly lower than 16.07% in the control group (P < 0.05). The satisfaction rate for injection in the observation group was 94.74%, which was significantly higher than 78.57% in the control group (P < 0.05).

Conclusion Optimizing the drug administration process can improve patient's comfort and tolerability during chemotherapy for multiple myeloma, reduce the incidence rate of adverse reactions, and has a high satisfaction rate for injection.