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重复经颅磁刺激对精神分裂症患者迟发性运动障碍的干预效果

Interventional effect of repetitive transcranial magnetic stimulation on tardive dyskinesia in schizophrenic patients

    摘要
  • 摘要:
    目的 探讨重复经颅磁刺激(rTMS)对精神分裂症患者迟发性运动障碍(TD)的干预效果。
    方法 选取105例精神分裂症患者为研究对象，随机分为1 Hz治疗组、10 Hz治疗组和对照组，每组35例。3组均给予rTMS治疗12周。比较3组的不自主运动评定量表(AIMS)、负性症状量表(SANS)、阳性和负性症状量表(PANSS)和治疗副反应量表(TESS)评分。检测患者的心电图、血常规、血生化、激素水平等生理指标。
    结果 治疗后, 1 Hz治疗组和10 Hz治疗组的AIMS总分低于治疗前，且1 Hz治疗组和10 Hz治疗组低于对照组，差异有统计学意义(P < 0.05)。1 Hz治疗组和10 Hz治疗组的AIMS减分率分别为68.6%和65.7%, 高于对照组的22.9%, 差异有统计学意义(P < 0.05)。治疗后, 1 Hz治疗组和10 Hz治疗组的SANS总分、PANSS总分低于治疗前，且1 Hz治疗组和10 Hz治疗组低于对照组，差异有统计学意义(P < 0.05)。1 Hz治疗组和10 Hz治疗组的AIMS总分、疗效、PANSS总分比较，差异无统计学意义(P>0.05)。3组治疗前后的TESS总分和生理指标比较，差异无统计学意义(P>0.05)。
    结论 1 Hz和10 Hz的rTMS均能有效改善精神分裂症患者的TD, 且安全性良好，无明显副反应和生理损害。

     

    Abstract:
    Objective To explore the interventional effect of repetitive transcranial magnetic stimulation (rTMS) on tardive dyskinesia (TD) in schizophrenic patients.
    Methods A total of 105 schizophrenic patients were selected as subjects and randomly divided into 1 Hz treatment group, 10 Hz treatment group and control group, with 35 patients in each group. All three groups received rTMS treatment for 12 weeks. The Abnormal Involuntary Movement Scale (AIMS), Scale for the Assessment of Negative Symptoms (SANS), Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Symptom Scale (TESS) scores were compared among the three groups. Physiological indicators such as electrocardiogram, blood routine, blood biochemistry and hormone levels were monitored.
    Results After treatment, the total AIMS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment, and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group (P < 0.05). The reduction rates of AIMS scores in the 1 Hz and 10 Hz treatment groups were 68.6% and 65.7%, respectively, which were significantly higher than the 22.9% in the control group (P < 0.05). After treatment, the total SANS and PANSS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment, and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group (P < 0.05). There was no statistically significant difference in the total AIMS score, efficacy and total PANSS score between the 1 Hz and 10 Hz treatment groups (P>0.05). There were no significant differences in the total TESS scores and physiological indicators among the three groups before and after treatment (P>0.05).
    Conclusion Both 1 Hz and 10 Hz rTMS can effectively improve TD in schizophrenic patients with good safety and have no significant side effects or physiological damage.

     

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