Research progress of microinflammatory state and disease severity in patients with chronic obstructive pulmonary disease
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摘要:
慢性阻塞性肺疾病(COPD)是一种常见的呼吸系统疾病，具有很高的发病率和病死率。目前, COPD的发病机制尚无明确定论。微炎症状态是指由于细菌、病毒、真菌感染等原因导致的某些病原体在体内生长繁殖，引起局部组织和全身性炎症反应，表现为全身循环中炎症标志蛋白及炎症细胞因子轻度持续增高。本文对微炎症状态与COPD的相关文献报道进行综述，总结微炎症状态导致机体促炎和抗炎机制，可造成肺部组织细胞的缺血和缺氧性破坏与损伤，进一步加剧肺部损伤。微炎症状态常见的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)以及白细胞介素(IL)等炎症因子与COPD病情严重程度密切相关，可能促进病情进展，持续影响患者肺功能、动脉血气及营养状况。
Abstract:Chronic obstructive pulmonary disease (COPD) is a common respiratory system disease, with high incidence rate and mortality. So far, the pathogenesis of COPD has not been clearly determined. Microinflammatory state refers to the growth and reproduction of certain pathogens in the body due to bacteria, viruses and fungi infections, which causes inflammatory response of local tissues and the whole body, it is manifested by a slight and continuous increase of inflammatory marker proteins and inflammatory cytokines in systemic circulation. This article reviewed the literature on microinflammatory state and COPD. It is concluded that microinflammatory state will lead to the imbalance of proinflammatory and anti-inflammatory mechanisms, which can cause ischemic and hypoxic destruction and injury of lung tissue cells, and further aggravate lung injury. The common inflammatory factors such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin (IL) in microinflammatory state are closely related to the severity of COPD, which may promote disease progression, continuously affect lung function, arterial blood gas and nutritional status of patients.
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[1] 翁光平, 邱丽莉, 王艳波. 慢阻肺急性加重期患者血清IL-37水平与免疫失衡的相关性[J]. 标记免疫分析与临床, 2021, 28(8): 1387-1391, 1420. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY202108028.htm [2] YANG I A, JENKINS C R, SALVI S S. Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment[J]. Lancet Respir Med, 2022, 10(5): 497-511. doi: 10.1016/S2213-2600(21)00506-3
[3] WU J H, GUO N F, CHEN X L, et al. Coexistence of micro-inflammatory and macrophage phenotype abnormalities in chronic kidney disease[J]. Int J Clin Exp Pathol, 2020, 13(2): 317-323.
[4] 吴芳, 王福诩, 龙欣, 等. 维持性血液透析患者生活质量与蛋白质能量消耗和微炎症状态的相关性研究[J]. 国际泌尿系统杂志, 2021, 41(2): 225-229. doi: 10.3760/cma.j.cn431460-20191016-00008 [5] 董晨明, 赵健雄, 李培杰, 等. 院内G-菌感染后全身炎症反应综合征的研究[J]. 中国危重病急救医学, 2003(11): 666-668. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWZB200311006.htm [6] 赵云侠, 陈文. 腹膜透析患者幽门螺杆菌感染及其对微炎症、营养状态的影响[J]. 临床与病理杂志, 2021, 41(3): 531-535. https://www.cnki.com.cn/Article/CJFDTOTAL-WYSB202103007.htm [7] CELLI B R, FABBRI L M, AARON S D, et al. An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal[J]. Am J Respir Crit Care Med, 2021, 204(11): 1251-1258. doi: 10.1164/rccm.202108-1819PP
[8] 陈忠仁, 欧宗兴, 王蕾, 等. NLRP3炎性小体与慢性阻塞性肺疾病大鼠肺功能相关性研究[J]. 临床肺科杂志, 2020, 25(8): 1167-1170. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFK202008009.htm [9] 钱建德, 宦才娟. 不同分级慢性阻塞性肺疾病患者免疫功能、炎症因子水平及其与肺功能的关系分析[J]. 浙江医学, 2021, 43(13): 1435-1438, 1443. doi: 10.12056/j.issn.1006-2785.2021.43.13.2020-3074 [10] 张晶, 栾晓嵘, 郝俊萍, 等. 慢性阻塞性肺疾病伴肺部感染者相关细胞因子的表达及其与肺功能的关系[J]. 中华医院感染学杂志, 2019, 29(13): 1954-1958. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201913010.htm [11] 黄莺, 皮小芹, 陈小茜. CPAP联合维生素营养支持治疗新生儿呼吸衰竭的效果观察[J]. 川北医学院学报, 2019, 34(4): 388-391. https://www.cnki.com.cn/Article/CJFDTOTAL-NOTH201904018.htm [12] ARIKAN-AYYILDIZ Z, KARAMAN M, FIRINCI F, et al. Effects of inhaled L-arginine administration in a murine model of acute asthma[J]. Iran J Allergy Asthma Immunol, 2014, 13(5): 317-323.
[13] SAINT-CRIQ V, LUGO-VILLARINO G, THOMAS M. Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases[J]. Ageing Res Rev, 2021, 66: 101235. doi: 10.1016/j.arr.2020.101235
[14] CARRETERO GÓMEZ J, MAFÉ NOGUEROLES M C, GARRACHÓN VALLO F, et al. Inflammation, malnutrition, and SARS-CoV-2 infection: a disastrous combination[J]. Rev Clin Esp, 2020, 220(8): 511-517. doi: 10.1016/j.rce.2020.07.007
[15] KORN T, HILTENSPERGER M. Role of IL-6 in the commitment of T cell subsets[J]. Cytokine, 2021, 146: 155654. doi: 10.1016/j.cyto.2021.155654
[16] KANG S J, NARAZAKI M, METWALLY H, et al. Historical overview of the interleukin-6 family cytokine[J]. J Exp Med, 2020, 217(5): e20190347. doi: 10.1084/jem.20190347
[17] LIN T L, CHEN W W, DING Z R, et al. Correlations between serum amyloid A, C-reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease[J]. J Clin Lab Anal, 2019, 33(4): e22831. doi: 10.1002/jcla.22831
[18] HASSAN A, JABBAR N. C-reactive protein as a predictor of severity in chronic obstructive pulmonary disease: an experience from a tertiary care hospital[J]. Cureus, 2022, 14(8): e28229.
[19] PANDEY S, GARG R, KANT S, et al. Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease[J]. Tzu Chi Med J, 2021, 33(1): 80-86. doi: 10.4103/tcmj.tcmj_198_19
[20] JANG D I, LEE A H, SHIN H Y, et al. The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics[J]. Int J Mol Sci, 2021, 22(5): 2719. doi: 10.3390/ijms22052719
[21] DUAN Y W, CHEN S X, LI Q Y, et al. Neuroimmune mechanisms underlying neuropathic pain: the potential role of TNF-α-necroptosis pathway[J]. Int J Mol Sci, 2022, 23(13): 7191. doi: 10.3390/ijms23137191
[22] DAS S S, SINGH S K, VERMA P, et al. Mitigating inflammation using advanced drug delivery by targeting TNF-α in lung diseases[J]. Future Med Chem, 2022, 14(2): 57-60. doi: 10.4155/fmc-2021-0225
[23] MIR H, KOUL P A, BHAT D, et al. A case-control study of tumor necrosis factor-alpha promoter polymorphism and its serum levels in patients with chronic obstructive pulmonary disease in Kashmir, North India[J]. Lung India, 2020, 37(3): 204-209. doi: 10.4103/lungindia.lungindia_477_19
[24] SINGH S, VERMA S K, KUMAR S, et al. Correlation of severity of chronic obstructive pulmonary disease with potential biomarkers[J]. Immunol Lett, 2018, 196: 1-10. doi: 10.1016/j.imlet.2018.01.004
[25] KUBYSHEVA N, BOLDINA M, ELISEEVA T, et al. Relationship of serum levels of IL-17, IL-18, TNF-α, and lung function parameters in patients with COPD, asthma-COPD overlap, and bronchial asthma[J]. Mediators Inflamm, 2020, 2020: 4652898.
[26] FENG Q, YU Y Z, MENG Q H. Blocking tumor necrosis factor-α delays progression of chronic obstructive pulmonary disease in rats through inhibiting MAPK signaling pathway and activating SOCS3/TRAF1[J]. Exp Ther Med, 2021, 22(5): 1311. doi: 10.3892/etm.2021.10746
[27] NAGATA K, NISHIYAMA C. IL-10 in mast cell-mediated immune responses: anti-inflammatory and proinflammatory roles[J]. Int J Mol Sci, 2021, 22(9): 4972. doi: 10.3390/ijms22094972
[28] OUYANG W, O'GARRA A. IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation[J]. Immunity, 2019, 50(4): 871-891. doi: 10.1016/j.immuni.2019.03.020
[29] 焦文妤, 尚家璐, 李树霞. 慢性阻塞性肺疾病患者血清补体C1q肿瘤坏死因子相关蛋白5与肺功能及炎症反应相关性研究[J]. 陕西医学杂志, 2019, 48(12): 1616-1618, 1621. doi: 10.3969/j.issn.1000-7377.2019.12.010 [30] JIANG S H, SHAN F L, ZHANG Y W, et al. Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD[J]. Int J Chron Obstruct Pulmon Dis, 2018, 13: 2483-2494. doi: 10.2147/COPD.S167192
[31] WEI B, TIAN T, LIU Y G. IL-10 combined with NGAL has diagnostic value for AECOPD combined with AKI[J]. Int J Chron Obstruct Pulmon Dis, 2020, 15: 637-644. doi: 10.2147/COPD.S245541
[32] QING H, DESROULEAUX R, ISRANI-WINGER K, et al. Origin and function of stress-induced IL-6 in murine models[J]. Cell, 2020, 182(6): 1660. doi: 10.1016/j.cell.2020.08.044
[33] KANG S J, TANAKA T, NARAZAKI M, et al. Targeting interleukin-6 signaling in clinic[J]. Immunity, 2019, 50(4): 1007-1023. doi: 10.1016/j.immuni.2019.03.026
[34] 何添标, 黎艳聪, 袁健志. AECOPD患者血清PCT、IL-6、CRP水平与肺通气功能的相关性研究[J]. 海南医学院学报, 2019, 25(6): 447-450. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201906012.htm [35] 许词, 贾彦巍. IL-6、NT-proBNP、CRP对COPD合并CPHD患者病情严重程度的预测价值[J]. 保健医学研究与实践, 2022, 19(11): 47-51. https://www.cnki.com.cn/Article/CJFDTOTAL-GXBJ202211010.htm [36] RUWANPURA S M, MCLEOD L, DOUSHA L F, et al. Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema[J]. Proc Natl Acad Sci U S A, 2022, 119(36): e2201494119. doi: 10.1073/pnas.2201494119
[37] WEI Y Y, ZHANG D W, YE J J, et al. Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease[J]. Biomedecine Pharmacother, 2022, 152: 113244. doi: 10.1016/j.biopha.2022.113244
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