Objective To observe the application effect of polyhexamethylene biguanide (PHMB) antibacterial dressing in the treatment of skin ulcer around the stoma in patients with enterostomy during radiotherapy and chemotherapy.

Methods A total of 65 patients with skin ulcer around the stoma during radiotherapy and chemotherapy were randomly divided into control group (34 cases) and observation group (31 cases). The control group was treated with silver ion dressing for skin ulcer around the stoma, while the observation group was treated with PHMB antibacterial dressing around the stoma. The healing rate of skin ulcer around the stoma, frequency of average dressing change, dressing cost at 4 weeks after treatment as well as Discoloration, Erosion, Tissue overgrowth (DET) score and ulcer status around the stoma were compared between the two groups at 2 and 4 weeks after treatment.

Results The healing rate of skin ulcer around the stoma in the observation group was (70.68±6.39)% at 4 weeks of treatment, which was higher than (57.76±12.82)% in the control group, and the dressing cost was less than that in the control group within 4 weeks (P < 0.05). There was no significant difference in the average dressing change frequency between the two groups within 4 weeks (P>0.05). At 2 and 4 weeks of treatment, the DET score and ulcer area around the stoma in the observation group were lower or smaller than those in the control group (P < 0.05).

Conclusion The use of PHMB antibacterial dressing in the treatment of skin ulcer around the stoma in patients with enterostomy during radiotherapy and chemotherapy can effectively control infection, promote ulcer healing, and has excellent economic cost-effectiveness.