自制鼻通膏联合中药敷脐治疗小儿肺经伏热型过敏性鼻炎的疗效观察

Effect of self-made Bitong Ointment combined with umbilical dressing of traditional Chinese medicine in treatment of children with pediatric allergic rhinitis differentiated as type of latent heat in the lung meridian

  • 摘要:
    目的 探讨自制鼻通膏联合中药敷脐治疗小儿肺经伏热型过敏性鼻炎的疗效。
    方法 选取小儿肺经伏热型过敏性鼻炎患者80例,随机分为观察组和对照组,每组40例。对照组给予氯雷他定治疗,观察组在对照组基础上加用自制鼻通膏联合中药敷脐治疗。治疗4周后评估患儿临床疗效、中医证候积分、气道应激反应、炎症因子、治疗安全性等。
    结果 观察组总有效率为95.00%(38/40), 高于对照组为77.50%(31/40)。治疗后,观察组主要中医症候积分包括喷嚏频繁、清稀鼻涕、嗅觉迟钝、气短懒言低于对照组。治疗后,观察组气道应激反应指标呼出气一氧化氮(FeNO)、脂质过氧化氢(LHP)、诱导型一氧化氮合酶(iNOS)水平均低于对照组。治疗后,观察组炎症因子单核细胞趋化蛋白-4(MCP-4)、半胱氨酸白三烯受体1(CysLTR1)、白介素-9(IL-9)水平低于对照组,差异均有统计学意义(P < 0.05)。治疗期间2组患者不良反应发生率为15.00%(6/40)、10.00%(4/40), 差异无统计学意义(P>0.05)。
    结论 自制鼻通膏联合中药敷脐治疗小儿肺经伏热型过敏性鼻炎疗效显著,能够改善患儿的中医症候,抑制气道应激反应,降低炎症因子水平表达,治疗安全性良好。

     

    Abstract:
    Objective To investigate the therapeutic effect of self-made Bitong Ointment combined with umbilical dressing of traditional Chinese medicine in the treatment of children with pediatric allergic rhinitis differentiated as type of latent heat in the lung meridian.
    Methods Eighty children with allergic rhinitis differentiated as type of latent heat in the lung meridian were randomly divided into observation group and control group, with 40 cases in each group. The control group was treated with loratadine, while the observation group was additionally treated with self-made Bitong Ointment and umbilical dressing of traditional Chinese medicine. After 4 weeks of treatment, the clinical effect, TCM syndrome score, airway stress response, inflammatory factors, and therapeutic safety were evaluated.
    Results The total effective rate in the observation group was 95.00% (38/40), which was higher than 77.50% (31/40) in the control group. After treatment, the scores of main TCM syndromes such as frequent sneezing, clear and thin nasal discharge, decreased sense of smell, shortness of breath, and reluctance to speak in the observation group were lower than those in the control group. After treatment, the levels of indicators of airway stress response such as exhaled nitric oxide (FeNO), lipid peroxide (LHP) and inducible nitric oxide synthase (iNOS) in the observation group were lower than those in the control group. After treatment, the levels of inflammatory factors such as monocyte chemoattractant protein-4 (MCP-4), cysteinyl leukotriene receptor 1 (CysLTR1), and interleukin-9 (IL-9) in the observation group were significantly lower than those in the control group (P < 0.05). The incidence rate of adverse reactions during treatment was 15.00% (6/40) in the observation groupand 10.00% (4/40) in the control group, with no significant difference between the two groups (P>0.05).
    Conclusion The combination of self-made Bitong Ointment combined with umbilical dressing of traditional Chinese medicine is effective in the treatment of children with pediatric allergic rhinitis differentiated as type of latent heat in the lung meridian, which can improve the TCM syndromes, inhibit the airway stress response, reduce the expression levels of inflammatory factors, and has good therapeutic safety.

     

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