基于Web of Science数据库分析2013—2022年生酮饮食的研究热点与趋势

Research hotspots and trends in ketogenic diet from 2013 to 2022 based on the Web of Science database

  • 摘要:
    目的 基于Web of Science(WOS)数据库分析生酮饮食相关文献,明确该领域的研究热点与趋势。
    方法 基于WOS核心数据库检索生酮饮食相关文献,时间范围为2013年1月1日—2022年12月31日。应用文献计量学方法和CiteSpace软件,对国家/地区、研究机构、发表期刊、关键词等文献特征进行统计学分析。
    结果 本研究共获取有效文献4 548篇,包括论著3 317篇、综述1 231篇。2013—2022年生酮饮食研究领域的发文量总体呈增长趋势,并于2021年达到峰值(756篇); 年被引频次呈逐年增长趋势,于2022年达到峰值(25 643次)。该领域发文量最多的国家和研究机构分别为美国(1 695篇,占37.27%)和约翰·霍普金斯大学(88篇,占1.93%), 且研究机构以高校为主。Nutrients载文量最多(241篇,占5.30%), Epilepsia的篇均被引频次最高(33.19次)。被引频次前10位的文献中, 5篇文献阐述了酮体在疾病治疗中的代谢与作用机制, 4篇文献的研究主题与癫痫相关。研究热点包括生酮饮食在癫痫与肥胖治疗中的应用和疗效评价,酮体的脂肪酸氧化、代谢、氧化应激、Warburg效应等常见调控机制,肠道菌群介导生酮饮食的作用研究; 研究趋势为生酮饮食在心力衰竭中的应用前景。
    结论 生酮饮食已被应用于多种疾病的治疗中,且其全球关注度持续增长,后续研究热点应聚焦于临床试验,以验证其临床疗效与耐受性。

     

    Abstract:
    Objective To analyze the literature related to ketogenic diet based on the Web of Science (WOS) database and clarify the research hotspots and trends in this field.
    Methods The literature related to ketogenic diet was retrieved from the core database of WOS from January 1, 2013 to December 31, 2022. Bibliometric methods and CiteSpace software were applied to statistically analyze the literature characteristics, including countries, regions, research institutions, publishing journals, and keywords.
    Results A total of 4, 548 valid articles were retrieved in this study, including 3, 317 original articles and 1, 231 reviews. The number of publications in the field of ketogenic diet research showed an overall increasing trend from 2013 to 2022, reaching the peak in 2021(756 articles). The annual citation frequency also exhibited a yearly increasing trend, reaching a peak of 25, 643 citations in 2022. The country with the highest number of publications was the United States (1, 695 articles, accounting for 37.27%), and the research institution with the most articles was Johns Hopkins University (88 articles, accounting for 1.93%). The majority of research institutions were universities. Nutrients journal had the highest number of published articles (241 articles, accounting for 5.30%), while Epilepsia journal had the highest average citation frequency per article (33.19 citations). Among the top 10 most cited articles, five focused on the metabolism and mechanism of action of ketone bodies in disease treatment, and four were related to epilepsy research. The research hotspots included the application and efficacy evaluation of ketogenic diet in the treatment of epilepsy and obesity, common regulatory mechanisms such as fatty acid oxidation, metabolism, oxidative stress, and Warburg effect of ketone bodies, and the role of gut microbiota in mediating the effects of ketogenic diet. The research trend pointed towards the application prospects of ketogenic diet in heart failure.
    Conclusion Ketogenic diet has been applied in the treatment of various diseases, and its global attention continues to grow. Future research hotspots should focus on clinical trials to verify its clinical efficacy and tolerability.

     

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