25-羟基维生素D、人β防御素-2及胰岛素样生长因子1水平与痤疮患者疾病严重程度的关系

杨悦漪; 林霞; 王丽兵

doi:10.7619/jcmp.20233195

25-羟基维生素D、人β防御素-2及胰岛素样生长因子1水平与痤疮患者疾病严重程度的关系

Relationships of 25-hydroxyvitamin D, human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients

摘要

摘要:
目的探讨外周血25-羟基维生素D25(OH) D、人β防御素-2(HBD-2)及胰岛素样生长因子1(IGF-1)水平与痤疮患者疾病严重程度的相关性。
方法选取128例寻常痤疮患者纳入痤疮组，另选取128例健康体检者纳入对照组。检测2组外周血25(OH) D、HBD-2及IGF-1水平。分析外周血25(OH) D、HBD-2及IGF-1水平与痤疮患者疾病严重程度的关系。分析痤疮患者外周血25(OH) D、HBD-2和IGF-1水平间的关系。采用受试者工作特征(ROC)曲线评估25(OH) D、HBD-2和IGF-1水平对重度痤疮的诊断价值。
结果痤疮组外周血25(OH) D水平低于对照组, IGF-1水平高于对照组，差异有统计学意义(P < 0.05); 2组HBD-2水平比较，差异无统计学意义(P>0.05)。痤疮组中，随着患者疾病严重程度加重，其外周血25(OH) D水平依次降低, IGF-1水平依次升高，差异有统计学意义(P < 0.05)。痤疮患者外周血25(OH) D水平与IGF-1水平、疾病严重程度呈负相关(r=-0.509、-0.586, P < 0.05), IGF-1水平与疾病严重程度呈正相关(r=0.547, P < 0.05), HBD-2水平与25(OH) D、IGF-1水平及疾病严重程度均无关(P>0.05)。外周血25(OH) D水平、IGF-1水平评估重度痤疮的敏感度分别为94.12%、61.26%, 特异度分别为70.59%、77.48%, 二者联合评估重度痤疮的敏感度为90.91%, 特异度为71.43%。
结论痤疮患者外周血25(OH) D水平降低, IGF-1水平升高，且其与疾病严重程度有关。25(OH) D、IGF-1水平联合评估重度痤疮的效能较好。

Abstract:
Objective To investigate the correlations of levels of 25-hydroxyvitamin D25(OH) D, human β-defencin-2 (HBD-2) and insulin-like growth factor 1(IGF-1) in peripheral blood with disease severity of acne patients.
Methods A total of 128 patients with acne vulgaris were included in the acne group and 128 healthy subjects were included in the control group. The levels of 25(OH) D, HBD-2 and IGF-1 in peripheral blood of two groups were detected. The relationships between the levels of 25(OH) D, HBD-2, IGF-1 in peripheral blood and the disease severity of acne patients were analyzed. The relationships between 25(OH) D, HBD-2 and IGF-1 levels in peripheral blood of acne patients were analyzed. The diagnostic value of 25(OH) D, HBD-2 and IGF-1 levels in severe acne was evaluated using receiver operating characteristic (ROC) curves.
Results The level of 25(OH) D in peripheral blood of the acne group was significantly lower than that of the control group, and the level of IGF-1 was significantly higher than that of the control group (P < 0.05). There was no significant difference in HBD-2 levels between the two groups (P>0.05). In the acne group, with the aggravation of disease severity, the level of 25(OH) D in peripheral blood was significantly decreased, and the level of IGF-1 was significantly increased (P < 0.05). The level of 25(OH) D in peripheral blood of acne patients was negatively correlated with the level of IGF-1 and the severity of the disease (r=-0.509, -0.586, P < 0.05), and the level of IGF-1 was positively correlated with the severity of the disease (r=0.547, P < 0.05). HBD-2 level was not correlated with 25(OH) D, IGF-1 level and disease severity (P>0.05). The sensitivity of peripheral blood 25(OH) D level and IGF-1 level in evaluating severity acne was 94.12%, 61.26%, respectively, and the specificity was 70.59%, 77.48%, respectively. The sensitivity and specificity of combined evaluation of severe acne were 90.91% and 71.43%, respectively.
Conclusion The level of 25(OH) D is decreased and the level of IGF-1 is increased in patients with acne, which is related to the severity of the disease. The combination of 25(OH) D and IGF-1 levels has a better efficacy in evaluating severity acne.

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