高级检索

肿痛安胶囊联合利伐沙班片治疗全膝关节置换术后下肢深静脉血栓的效果研究

Effect of Zhongtong'an Capsules combined with rivaroxaban tables in treating deep venous thrombosis of lower extremities after total knee arthroplasty

    摘要
  • 摘要:
    目的 观察肿痛安胶囊联合利伐沙班片对全膝关节置换术后下肢深静脉血栓(DVT)的影响。
    方法 将82例患者随机分为对照组和实验组, 每组41例。对照组患者术后给予利伐沙班片口服，实验组在对照组基础上口服肿痛安胶囊。比较2组患者主要结局指标(下肢DVT的发生情况)、次要结局指标下肢周径、股深静脉血流速度、全血高切黏度、全血低切黏度、红细胞压积、血浆黏度指数、血清凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)、血浆D-二聚体(D-D)、疗效疼痛视觉模拟量表(VAS)评分、美国特种外科医院(HSS)膝关节量表评分。
    结果 治疗14 d后，实验组下肢DVT发生率为9.76%(4/41), 低于对照组的31.71%(13/41), 差异有统计学意义(χ2=6.011, P < 0.05)。治疗7、14 d后，与对照组相比，实验组静脉血流速度加快，下肢周径差减小，差异有统计学意义(P < 0.05)。治疗7、14 d后，实验组各项血液流变学相关指标均低于对照组，差异有统计学意义(P < 0.05)。治疗7、14 d后，实验组PT和APTT长于对照组, FIB和D-D水平低于对照组，差异有统计学意义(P < 0.05)。治疗7、14 d后, 2组VAS评分均降低, HSS评分均升高，且实验组VAS评分低于对照组, HSS评分高于对照组，差异均有统计学意义(P < 0.05)。
    结论 肿痛安胶囊联合利伐沙班片可有效改善膝关节置换术患者术后血液高凝状态，减少术后DVT的形成。

     

    Abstract:
    Objective To observe the effect of Zhongtong'an Capsules combined with rivaroxaban tablets on deep venous thrombosis (DVT) of lower extremities after total knee arthroplasty.
    Methods A total of 82 patients were randomly divided into control group and experimental group, with 41 cases in each group. The control group was treated with rivaroxaban tablets after surgery, while the experimental group was treated with oral administration of Zhongtong'an Capsules on the basis of the control group. The main outcome indicators (occurrence of DVT of lower extremities), secondary outcome indicatorscircumference of lower extremities, blood flow velocity of femoral deep vein, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, plasma viscosity index, serum prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and plasma D-dimer (D-D), and therapeutic effectsthe Visual Analogue Scale (VAS) score for pain, score of American Hospital for Special Surgery (HSS) forknee functionwere compared between the two groups.
    Results After 14 days of treatment, the incidence of DVT of lower extremities in the experimental group was 9.76% (4/41), which was significantly lower than 31.71%(13/41) in the control group (χ2=6.011, P < 0.05). Compared with the control group, the experimental group had faster venous blood flow velocity and reduced circumference of lower extremities after 7 and 14 days of treatment (P < 0.05). After 7 and 14 days of treatment, all the hemorheological-related indicators in the experimental group were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the PT and APTT in the experimental group were significantly longer than those in the control group, while the FIB and D-D levels were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the VAS scores decreased and the HSS scores increased significantly in both groups, and the VAS scores in the experimental group were significantly lower than those in the control group, while the HSS scores were significantly higher than those in the control group (P < 0.05).
    Conclusion Zhongtong'an Capsules combined with rivaroxaban tablets can effectively improve the hypercoagulable state of patients after knee arthroplasty and reduce the formation of postoperative DVT.

     

    • HTML全文
    • 参考文献(21)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回