Objective To observe the effect of risperidone combined with clozapine in the treatment of vagrants with schizophrenia and its influence on social function of the patients.

Methods Eighty patients with vagrant schizophrenia were selected as the study objects by a prospective randomized controlled trial, and were randomly divided into control group (40 cases) and observation group (40 cases). The control group was treated with risperidone, and the observation group was treated with risperidone and clozapine. Both groups received continuous treatment for 8 weeks. The clinical effects of the two groups were observed. The activities of daily living, rehabilitationInpatient Psychiatric Rehabilitation Efficacy Rating Scale (IPROS) score, social function, myocardial enzyme profilelactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB) in the two groups before treatment and eight weeks after treatment were compared. The adverse reactions of the two groups were statistically analyzed.

Results The total effective rate of treatment in the observation group was higher than that of the control group (90.00% versus 72.50%, P < 0.05). After eight weeks of treatment, the abilities of daily living and social function of the two groups were stronger than before treatment, and the observation group was stronger than the control group. At 8 weeks of treatment, IPROS scores in two groups were lower than before treatment, and observation group was lower than control group (P < 0.05). After 8 weeks of treatment, LDH, CK and CK-MB levels in two groups were higher than before treatment (P < 0.05), but there was no statistical significant between-group difference (P > 0.05).

Conclusion Risperidone combined with clozapine has a significant effect in thetreatment of vagrants with schizophrenia, which can enhance the patients'daily living ability and social ability, improve the rehabilitation status, and does not increase the adverse reactions.